Electroacupuncture accelerated the expression of c-fos protooncogene in dopaminergic neurons in the ventral tegmental area of the rat

Qing Ping Ma, Yan Zhou, Ji Sheng Han

Research output: Journal PublicationArticlepeer-review

12 Citations (Scopus)

Abstract

The mesolimbic dopaminergic system has been implicated in mediating morphine and electroacupuncture analgesia. In the present study, Fos immunoreactivity was used as a marker of neuronal activity to investigate if electroacupuncture could activate the dopaminergic neurons in the midbrain. Electroacupuncture stimulation significantly increased the number of Fos-positive dopaminergic neurons in the ventral tegmental area (VTA), whereas no significant c-fos expression in the dopaminergic neurons was observed in the substantia nigra (SN). These results indicate that the VTA rather than the SN may play a role in mediating electroacupuncture analgesia

Original languageEnglish
Pages (from-to)217-222
Number of pages6
JournalInternational Journal of Neuroscience
Volume70
Issue number3-4
DOIs
Publication statusPublished - 1993
Externally publishedYes

Keywords

  • C-fos protooncogene
  • Dopamine
  • Electroacupuncture
  • Ventral tegmental area

ASJC Scopus subject areas

  • General Neuroscience

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