Optical coherence tomography angiography (OCTA) requires high transverse sampling density for visualizing retinal and choroidal capillaries. Low transverse sampling causes digital resolution degradation, such as the angiograms in wide-field OCTA. In this paper, we propose to address this problem using deep learning. We conducted extensive experiments on converting the centrally cropped 3 × 3 mm2 field of view (FOV) of the 8 × 8 mm2 foveal OCTA images (a sampling density of 22.9 µm) to the native 3 × 3 mm2 en face OCTA images (a sampling density of 12.2 µm). We employed a cycle-consistent adversarial network architecture in this conversion. The quantitative analysis using the perceptual similarity measures shows the generated OCTA images are closer to the native 3 × 3 mm2 scans. Besides, the results show the proposed method could also enhance the signal-to-noise ratio. We further applied our method to enhance diseased cases and calculate vascular biomarkers, which demonstrates its generalization performance and clinical perspective.
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Atomic and Molecular Physics, and Optics
- Electrical and Electronic Engineering