Digital resolution enhancement in low transverse sampling optical coherence tomography angiography using deep learning

Ting Zhou, Jianlong Yang, Kang Zhou, Liyang Fang, Yan Hu, Jun Cheng, Yitian Zhao, Xiangping Chen, Shenghua Gao, Jiang Liu

Research output: Journal PublicationArticlepeer-review

Abstract

Optical coherence tomography angiography (OCTA) requires high transverse sampling density for visualizing retinal and choroidal capillaries. Low transverse sampling causes digital resolution degradation, such as the angiograms in wide-field OCTA. In this paper, we propose to address this problem using deep learning. We conducted extensive experiments on converting the centrally cropped 3 × 3 mm2 field of view (FOV) of the 8 × 8 mm2 foveal OCTA images (a sampling density of 22.9 µm) to the native 3 × 3 mm2 en face OCTA images (a sampling density of 12.2 µm). We employed a cycle-consistent adversarial network architecture in this conversion. The quantitative analysis using the perceptual similarity measures shows the generated OCTA images are closer to the native 3 × 3 mm2 scans. Besides, the results show the proposed method could also enhance the signal-to-noise ratio. We further applied our method to enhance diseased cases and calculate vascular biomarkers, which demonstrates its generalization performance and clinical perspective.

Original languageEnglish
Pages (from-to)1664-1678
Number of pages15
JournalOSA Continuum
Volume3
Issue number6
DOIs
Publication statusPublished - 15 Jun 2020
Externally publishedYes

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Electrical and Electronic Engineering

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