Development of Robust Chitosan-Silica Class II hybrid coatings with antimicrobial properties for titanium implants

Zach Gouveia, Hiran Perinpanayagam, Jesse Zhu

Research output: Journal PublicationArticlepeer-review

10 Citations (Scopus)

Abstract

The purpose of this studywas to develop robust class II organic-inorganic films as antibacterial coatings on titanium alloy (Ti6Al4V) implants. Coating materials were prepared from organic chitosan (20-80wt.%) coupled by 3-glycydoxytrimethoxysilane (GPTMS)with inorganic tetraethoxysilane (TEOS). These hybrid networks were imbedded with antimicrobial silver nanoparticles (AgNPs) and coated onto polished and acid-etched Ti6Al4V substrates. Magic-angle spinning nuclear magnetic resonance (13CMAS-NMR), attenuated total reflectance Fourier-transform infrared spectroscopy (ATR-FTIR) and the ninhydrin assay, confirmed the presence and degree of covalent crosslinking (91%) between chitosan and GPTMS. Scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS) identified surface roughness and microtopography on thin films and confirmed homogeneous distribution of elements throughout the coating. Cross-hatch and tensile adhesion testing demonstrated the robustness and adherence (15-20 MPa) of hybrid coatings to acid-etched titanium substrates. Staphylococcus aureus and Escherichia coli cultures and their biofilm formation were inhibited by all hybrid coatings. Antibacterial effects increased markedly for coatings loaded with AgNPs and appeared to increase with chitosan content in biofilm assays. These results are promising in the development of class II hybrid materials as robust and highly adherent antibacterial films on Ti6Al4V implants.

Original languageEnglish
Article number534
JournalCoatings
Volume10
Issue number6
DOIs
Publication statusPublished - 1 Jun 2020
Externally publishedYes

Keywords

  • Antibacterial coating
  • Chitosan
  • Silver nanoparticles
  • Sol-gel
  • Thin films
  • Titanium implants

ASJC Scopus subject areas

  • Surfaces and Interfaces
  • Surfaces, Coatings and Films
  • Materials Chemistry

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