Development of multifunctional Si-Ca-PEG-nAg sol–gel implant coatings from calcium-2-ethoxyethoxide

Zach Gouveia, Hiran Perinpanayagam, Jesse Zhu

Research output: Journal PublicationArticlepeer-review

1 Citation (Scopus)


Titanium implant success is compromised by microbial biofilms and aseptic loosening. This research aimed to develop robust multifunctional class II organic-inorganic hybrid coatings for implants with osteoconductive and antibacterial properties. 3-Glycidoxypropyltrimethoxysilane was coupled with organic polymer poly(ethylene) glycol-diamine (PEG-NH2) for integration into an inorganic sol backbone composed of tetraethoxysilane and calcium, which was sourced from newly synthesized calcium-2-ethoxyethoxide. Nuclear magnetic resonance and attenuated total reflectance Fourier transform infrared spectroscopy confirmed synthesis of precursors and the structure of coating constituents. Scanning electron microscopy and energy-dispersive X-ray spectroscopy (EDS) demonstrated homogenous coatings, micro-topographical surface features, and apatite-like ex vivo mineralization in simulated body fluid. Tensile adhesion testing demonstrated robust and highly adherent (15.1 ± 3.3 MPa) coatings on titanium substrates. Hybrid coatings imbedded with silver nanoparticles (nAg) significantly inhibited (P < 0.05) Staphylococcus aureus and Escherichia coli planktonic cultures and biofilm formation. These Si-Ca-PEG-nAg hybrid coatings for titanium implants offer robust multifunctional features.

Original languageEnglish
Pages (from-to)1177-1189
Number of pages13
JournalJournal of Coatings Technology Research
Issue number4
Publication statusPublished - Jul 2021
Externally publishedYes


  • Antibacterial coating
  • Biointerfaces
  • Class II hybrid
  • Silver nanoparticles
  • Sol–gel
  • Thin films
  • Titanium implants

ASJC Scopus subject areas

  • Chemistry (all)
  • Surfaces and Interfaces
  • Surfaces, Coatings and Films
  • Colloid and Surface Chemistry


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