Development of an integrated model of cardiovascular and pulmonary physiology for the evaluation of mechanical ventilation strategies

Anup Das; Mainul Haque; Marc Chikhani; Wenfei Wang; Tayyba Ali; Oana Cole; Jonathan G. Hardman; Declan G. Bates

doi:10.1109/EMBC.2015.7319592

Development of an integrated model of cardiovascular and pulmonary physiology for the evaluation of mechanical ventilation strategies

Anup Das, Mainul Haque, Marc Chikhani, Wenfei Wang, Tayyba Ali, Oana Cole, Jonathan G. Hardman, Declan G. Bates

Research output: Chapter in Book/Conference proceeding › Conference contribution › peer-review

11 Citations (Scopus)

Abstract

We describe the development of an integrated cardiovascular and pulmonary model for use in the investigation of novel mechanical ventilation strategies in the intensive care unit. The cardiac model includes the cardiac chambers, the pulmonary circulation and the systemic circulation. The modeling of complex mechanisms for vascular segments, time varying elastance functions of cardiovascular components and the effect of vascular resistances, in health and disease under the influence of mechanical ventilation is investigated. The resulting biomedical simulator can aid in understanding the underlying pathophysiology of critically-ill patients and facilitate the development of more effective therapeutic strategies for evaluation in clinical trials.

Original language	English
Title of host publication	2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	5319-5322
Number of pages	4
ISBN (Electronic)	9781424492718
DOIs	https://doi.org/10.1109/EMBC.2015.7319592
Publication status	Published - 4 Nov 2015
Externally published	Yes
Event	37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015 - Milan, Italy Duration: 25 Aug 2015 → 29 Aug 2015

Publication series

Name	Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Volume	2015-November
ISSN (Print)	1557-170X

Conference

Conference	37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015
Country/Territory	Italy
City	Milan
Period	25/08/15 → 29/08/15

ASJC Scopus subject areas

Signal Processing
Biomedical Engineering
Computer Vision and Pattern Recognition
Health Informatics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1109/EMBC.2015.7319592

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Das, A., Haque, M., Chikhani, M., Wang, W., Ali, T., Cole, O., Hardman, J. G., & Bates, D. G. (2015). Development of an integrated model of cardiovascular and pulmonary physiology for the evaluation of mechanical ventilation strategies. In 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015 (pp. 5319-5322). Article 7319592 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; Vol. 2015-November). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2015.7319592

Das, Anup ; Haque, Mainul ; Chikhani, Marc et al. / Development of an integrated model of cardiovascular and pulmonary physiology for the evaluation of mechanical ventilation strategies. 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015. Institute of Electrical and Electronics Engineers Inc., 2015. pp. 5319-5322 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

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title = "Development of an integrated model of cardiovascular and pulmonary physiology for the evaluation of mechanical ventilation strategies",

abstract = "We describe the development of an integrated cardiovascular and pulmonary model for use in the investigation of novel mechanical ventilation strategies in the intensive care unit. The cardiac model includes the cardiac chambers, the pulmonary circulation and the systemic circulation. The modeling of complex mechanisms for vascular segments, time varying elastance functions of cardiovascular components and the effect of vascular resistances, in health and disease under the influence of mechanical ventilation is investigated. The resulting biomedical simulator can aid in understanding the underlying pathophysiology of critically-ill patients and facilitate the development of more effective therapeutic strategies for evaluation in clinical trials.",

author = "Anup Das and Mainul Haque and Marc Chikhani and Wenfei Wang and Tayyba Ali and Oana Cole and Hardman, {Jonathan G.} and Bates, {Declan G.}",

note = "Publisher Copyright: {\textcopyright} 2015 IEEE.; 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015 ; Conference date: 25-08-2015 Through 29-08-2015",

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doi = "10.1109/EMBC.2015.7319592",

language = "English",

series = "Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS",

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Das, A, Haque, M, Chikhani, M, Wang, W, Ali, T, Cole, O, Hardman, JG & Bates, DG 2015, Development of an integrated model of cardiovascular and pulmonary physiology for the evaluation of mechanical ventilation strategies. in 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015., 7319592, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, vol. 2015-November, Institute of Electrical and Electronics Engineers Inc., pp. 5319-5322, 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015, Milan, Italy, 25/08/15. https://doi.org/10.1109/EMBC.2015.7319592

Development of an integrated model of cardiovascular and pulmonary physiology for the evaluation of mechanical ventilation strategies. / Das, Anup; Haque, Mainul; Chikhani, Marc et al.
2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015. Institute of Electrical and Electronics Engineers Inc., 2015. p. 5319-5322 7319592 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; Vol. 2015-November).

Research output: Chapter in Book/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Development of an integrated model of cardiovascular and pulmonary physiology for the evaluation of mechanical ventilation strategies

AU - Das, Anup

AU - Haque, Mainul

AU - Chikhani, Marc

AU - Wang, Wenfei

AU - Ali, Tayyba

AU - Cole, Oana

AU - Hardman, Jonathan G.

AU - Bates, Declan G.

PY - 2015/11/4

Y1 - 2015/11/4

N2 - We describe the development of an integrated cardiovascular and pulmonary model for use in the investigation of novel mechanical ventilation strategies in the intensive care unit. The cardiac model includes the cardiac chambers, the pulmonary circulation and the systemic circulation. The modeling of complex mechanisms for vascular segments, time varying elastance functions of cardiovascular components and the effect of vascular resistances, in health and disease under the influence of mechanical ventilation is investigated. The resulting biomedical simulator can aid in understanding the underlying pathophysiology of critically-ill patients and facilitate the development of more effective therapeutic strategies for evaluation in clinical trials.

AB - We describe the development of an integrated cardiovascular and pulmonary model for use in the investigation of novel mechanical ventilation strategies in the intensive care unit. The cardiac model includes the cardiac chambers, the pulmonary circulation and the systemic circulation. The modeling of complex mechanisms for vascular segments, time varying elastance functions of cardiovascular components and the effect of vascular resistances, in health and disease under the influence of mechanical ventilation is investigated. The resulting biomedical simulator can aid in understanding the underlying pathophysiology of critically-ill patients and facilitate the development of more effective therapeutic strategies for evaluation in clinical trials.

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DO - 10.1109/EMBC.2015.7319592

M3 - Conference contribution

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T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS

SP - 5319

EP - 5322

BT - 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015

PB - Institute of Electrical and Electronics Engineers Inc.

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Y2 - 25 August 2015 through 29 August 2015

ER -

Das A, Haque M, Chikhani M, Wang W, Ali T, Cole O et al. Development of an integrated model of cardiovascular and pulmonary physiology for the evaluation of mechanical ventilation strategies. In 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015. Institute of Electrical and Electronics Engineers Inc. 2015. p. 5319-5322. 7319592. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). doi: 10.1109/EMBC.2015.7319592

Development of an integrated model of cardiovascular and pulmonary physiology for the evaluation of mechanical ventilation strategies

Abstract

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Conference

ASJC Scopus subject areas

UN SDGs

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