Design principle in biosensing: Critical analysis based on graphitic carbon nitride (G-C3N4) photoelectrochemical biosensor

Sze Shin Low, Zetao Chen, Yaru Li, Yanli Lu, Qingjun Liu

Research output: Journal PublicationReview articlepeer-review

19 Citations (Scopus)

Abstract

Photoelectrochemical (PEC) biosensing has been attracting increasing attention as the generation of PEC current resulting from the biological interactions between biorecognition element and analyte has rendered PEC biosensor with high sensitivity and low detection limit. This review provides a panoramic snapshot of this dynamically developing field, with special emphasis on the design principle in biosensing, critically analyzing graphitic carbon nitride (g–C3N4)–based PEC biosensor. The basis and synthesis approaches for g-C3N4 are summarized, detailing the recent work done. This review highlights the novel concept of g–C3N4–based PEC biosensor based on three design principles: turn-on, turn-off and ratiometric, providing comprehensive design guidelines for researchers to develop more advanced PEC biosensors. Finally, future outlook and challenges for the progression of PEC biosensor are also evaluated and discussed. This work will serve as a useful and informative source for interested audience regarding the latest developments of g–C3N4–based biosensor in the field of PEC bioanalysis.

Original languageEnglish
Article number116454
JournalTrAC - Trends in Analytical Chemistry
Volume145
DOIs
Publication statusPublished - Dec 2021
Externally publishedYes

Keywords

  • Bioanalysis strategies
  • Biosensor
  • Design principle
  • Graphitic carbon nitride
  • Photoelectrochemistry

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy

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