CuO-GO-Ag; Green Synthesis With Fagonia Arabica and Biomedical Potential is a Bioinspired Nano Theranostics Composite

Sammia Shahid, Sana Mansoor, Mohsin Javed, Shahid Iqbal, Umair Yousaf, Hashem O. Alsaab, Nasser S. Awwad, Hala A. Ibrahium, Rami M. Alzhrani, Mashael D. Alqahtani, Nissren Tamam, Eslam B. Elkaeed, Sabah Zaman, Muhammad Nazim Sarwar, Tauheeda Riaz

Research output: Journal PublicationArticlepeer-review

3 Citations (Scopus)


In this study, a green synthesis strategy was used to construct CuO-GO-Ag nanocomposites (NCs) by using biological components of Fagonia arabica. Copper Oxide (CuO) nanoparticles and silver (Ag) nanoparticles were fabricated by using a plant extract of Fagonia arabica. Graphene oxide was synthesized by hummer’s method and hydrothermal approach. The characterization techniques used in this work were Energy Dispersive X-ray (EDX), Scanning electron microscopy (SEM), X-ray Diffraction (XRD), and ultra-violet visible spectroscopy (UV-Vis). As an innovative approach graphene oxide (GO) was firstly assorted with green synthesized CuO NPs and then Ag nanoparticles were incorporated to form amalgamated CuO-GO-Ag nanocomposite (NCs). The anti-inflammatory and antioxidant activity of nanocomposite were examined. The anti-inflammatory and antioxidant ability of the nanocomposite were evaluated by UV-Visible spectroscopy. Results reveal that biologically synthesized CuO-GO-Ag NCs have high scavenging and inflammation reduction potential as compared to standards (ascorbic acid, diclofenac sodium). CuO-GO-Ag showed that scavenging efficiency for 0.3 mg/ml is 57.40% and for 0.5 mg/ml is 74.24% while scavenging efficiency for standard (ascorbic acid) is 44.22% for 0.3 mg/ml and 58.42% for 0.5 mg/ml. Likewise, CuO-GO-Ag nanocomposite showed a % inhibition value of 46.59 and 87.80 at 0.1 mg/ml and 0.5 mg/ml while diclofenac sodium showed a % inhibition value of 10.98 and 35.37 a similar concentration. Fagonia arabica seems to be a good source for acclimating the potential of NCs and nanoparticles toward different increased biological activities, according to the findings.

Original languageEnglish
Article number875148
JournalFrontiers in Materials
Publication statusPublished - 1 Apr 2022
Externally publishedYes


  • bioinspired
  • Fagonia arabica
  • inhibition
  • nanocomposite
  • scavenging efficiency

ASJC Scopus subject areas

  • Materials Science (miscellaneous)


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