COVID-19 infection, admission and death among people with rare autoimmune rheumatic disease in England: results from the RECORDER project

Megan Rutter, Peter C. Lanyon, Matthew J. Grainge, Richard Hubbard, Emily Peach, Mary Bythell, Peter Stilwell, Jeanette Aston, Sarah Stevens, Fiona A. Pearce

Research output: Journal PublicationArticlepeer-review

1 Citation (Scopus)

Abstract

OBJECTIVES: To calculate the rates of COVID-19 infection and COVID-19-related death among people with rare autoimmune rheumatic diseases (RAIRD) during the first wave of the COVID-19 pandemic in England compared with the general population. METHODS: We used Hospital Episode Statistics to identify all people alive on 1 March 2020 with ICD-10 codes for RAIRD from the whole population of England. We used linked national health records (demographic, death certificate, admissions and PCR testing data) to calculate rates of COVID-19 infection and death up to 31 July 2020. Our primary definition of COVID-19-related death was mention of COVID-19 on the death certificate. General population data from Public Health England and the Office for National Statistics were used for comparison. We also describe COVID-19-related hospital admissions and all-cause deaths. RESULTS: We identified a cohort of 168 680 people with RAIRD, of whom 1874 (1.11%) had a positive COVID-19 PCR test. The age-standardized infection rate was 1.54 (95% CI: 1.50, 1.59) times higher than in the general population. A total of 713 (0.42%) people with RAIRD died with COVID-19 on their death certificate and the age-sex-standardized mortality rate for COVID-19-related death was 2.41 (2.30-2.53) times higher than in the general population. There was no evidence of an increase in deaths from other causes in the RAIRD population. CONCLUSIONS: During the first wave of COVID-19 in England, people with RAIRD had a 54% increased risk of COVID-19 infection and more than twice the risk of COVID-19-related death compared with the general population. These increases were seen despite shielding policies.

Original languageEnglish
Pages (from-to)3161-3171
Number of pages11
JournalRheumatology
Volume61
Issue number8
DOIs
Publication statusPublished - 3 Aug 2022
Externally publishedYes

Keywords

  • coronavirus
  • COVID-19
  • epidemiology
  • infection
  • mortality
  • rare autoimmune rheumatic diseases
  • shielding

ASJC Scopus subject areas

  • Rheumatology
  • Pharmacology (medical)

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