Core-Shell fibers: Design, roles, and controllable release strategies in tissue engineering and drug delivery

Muhammad Faiq Abdullah, Tamrin Nuge, Andri Andriyana, Bee Chin Ang, Farina Muhamad

Research output: Journal PublicationReview articlepeer-review

40 Citations (Scopus)

Abstract

The key attributes of core-shell fibers are their ability to preserve bioactivity of incorporated-sensitive biomolecules (such as drug, protein, and growth factor) and subsequently control biomolecule release to the targeted microenvironments to achieve therapeutic effects. Such qualities are highly favorable for tissue engineering and drug delivery, and these features are not able to be offered by monolithic fibers. In this review, we begin with an overview on design requirement of core-shell fibers, followed by the summary of recent preparation methods of core-shell fibers, with focus on electrospinning-based techniques and other newly discovered fabrication approaches. We then highlight the importance and roles of core-shell fibers in tissue engineering and drug delivery, accompanied by thorough discussion on controllable release strategies of the incorporated bioactive molecules from the fibers. Ultimately, we touch on core-shell fibers-related challenges and offer perspectives on their future direction towards clinical applications.

Original languageEnglish
Article number2008
JournalPolymers
Volume11
Issue number12
DOIs
Publication statusPublished - 1 Dec 2019
Externally publishedYes

Keywords

  • Core-shell fibers
  • Drug delivery
  • Release strategy
  • Scaffolds
  • Tissue engineering

ASJC Scopus subject areas

  • Chemistry (all)
  • Polymers and Plastics

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