TY - JOUR
T1 - CandiVF - Candida albicans virulence factor database
AU - Tongchusak, Songsak
AU - Chaiyaroj, Sansanee C.
AU - Veeramani, Anitha
AU - Koh, Judice L.Y.
AU - Brusic, Vladimir
N1 - Funding Information:
This project has been funded in part (JLYK and VB) with the USA Federal funds from the National Institute of Allergy and Infectious Diseases, National Institute of Health, Department of Health and Human Services, under Grant No. 5 U19 AI56541 and Contract No. HHSN266200400085C.
PY - 2005/12
Y1 - 2005/12
N2 - Candida albicans is a pathogen commonly infecting patients who receive immunosuppressive drug therapy, long-term catheterization, or those who suffer from acquired immune deficiency syndrome (AIDS). The major factor accountable for pathogenicity of C. albicans is host immune status. Various virulence molecules, or factors, of are also responsible for the disease progression. Virulence proteins are published in public databases but they normally lack detailed functional annotations. We have developed CandiVF, a specialized database of C. albicans virulence factors (http://antigen.i2r.a-star.edu.sg/ Templar/DB/CandiVF/) to facilitate efficient extraction and analysis of data aimed to assist research on immune responses, pathogenesis, prevention, and control of candidiasis. CandiVF contains a large number of annotated virulence proteins, including secretory, cell wall-associated, membrane, cytoplasmic, and nuclear proteins. This database has in-built bioinformatics tools including keyword and BLAST search, visualization of 3D-structures, HLA-DR epitope prediction, virulence descriptors, and virulence factors ontology.
AB - Candida albicans is a pathogen commonly infecting patients who receive immunosuppressive drug therapy, long-term catheterization, or those who suffer from acquired immune deficiency syndrome (AIDS). The major factor accountable for pathogenicity of C. albicans is host immune status. Various virulence molecules, or factors, of are also responsible for the disease progression. Virulence proteins are published in public databases but they normally lack detailed functional annotations. We have developed CandiVF, a specialized database of C. albicans virulence factors (http://antigen.i2r.a-star.edu.sg/ Templar/DB/CandiVF/) to facilitate efficient extraction and analysis of data aimed to assist research on immune responses, pathogenesis, prevention, and control of candidiasis. CandiVF contains a large number of annotated virulence proteins, including secretory, cell wall-associated, membrane, cytoplasmic, and nuclear proteins. This database has in-built bioinformatics tools including keyword and BLAST search, visualization of 3D-structures, HLA-DR epitope prediction, virulence descriptors, and virulence factors ontology.
KW - Candidiasis
KW - Fungal diseases
KW - Immunoinformatics
KW - T-cell epitopes
UR - http://www.scopus.com/inward/record.url?scp=28844432624&partnerID=8YFLogxK
U2 - 10.1007/s10989-005-9268-5
DO - 10.1007/s10989-005-9268-5
M3 - Article
AN - SCOPUS:28844432624
SN - 1573-3149
VL - 11
SP - 271
EP - 277
JO - International Journal of Peptide Research and Therapeutics
JF - International Journal of Peptide Research and Therapeutics
IS - 4
ER -