Biomineralizing Dental Resin Empowered by Bioactive Amphiphilic Composite Nanoparticles

Ailing Li, Yang Cui, Shan Gao, Qiuju Li, Liju Xu, Xiaohui Meng, Yanmei Dong, Xiaoling Liu, Dong Qiu

Research output: Journal PublicationArticlepeer-review

5 Citations (Scopus)


Adhesive failure due to resin contraction is one of the major reasons for dental restoration failure, which leads to the exposure of dentinal tubules, and remineralization in saliva would provide a great solution for the above problem. In this study, bioactive amphiphilic raspberry-like composite nanoparticles were used as fillers for resin composites, which have good compatibility with the resin matrix and dispersed well in the matrix. Thus, the resin composites showed improved mechanical property and resistance to water sorption and solubility. Furthermore, the incorporation of bioactive nanoparticles endued the resin composites with bioactivity, forming apatite on resin composites upon reacting with artificial saliva within seven days, inducing denser mineral precipitation on the dentin surface and stimulating human dental pulp cell attachment and proliferation. Therefore, this bioactive nanoparticle filled composite resin may offer great benefits for dental restoration.

Original languageEnglish
Pages (from-to)1660-1666
Number of pages7
JournalACS Applied Bio Materials
Issue number4
Publication statusPublished - 15 Apr 2019


  • bioactive composite nanoparticles
  • dental restoration resin composites
  • dentine
  • remineralization

ASJC Scopus subject areas

  • Biochemistry, medical
  • Chemistry (all)
  • Biomedical Engineering
  • Biomaterials


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