Biodiversity, Biochemical Profiling, and Pharmaco-Commercial Applications of Withania somnifera: A Review

Harshita Gaurav, Divyanshu Yadav, Ankita Maurya, Himanshu Yadav, Ramanand Yadav, Amritesh Chandra Shukla, Minaxi Sharma, Vijai Kumar Gupta, Javier Palazon

Research output: Journal PublicationReview articlepeer-review

21 Citations (Scopus)

Abstract

Withania somnifera L. Dunal (Ashwagandha), a key medicinal plant native to India, is used globally to manage various ailments. This review focuses on the traditional uses, botany, phytochemistry, and pharmacological advances of its plant-derived constituents. It has been reported that at least 62 crucial and 48 inferior primary and secondary metabolites are present in the W. somnifera leaves, and 29 among these found in its roots and leaves are chiefly steroidal compounds, steroidal lactones, alkaloids, amino acids, etc. In addition, the whole shrub parts possess various medicinal activities such as anti-leukotriene, antineoplastic, analgesic, anti-oxidant, immunostimulatory, and rejuvenating properties, mainly observed by in vitro demonstration. However, the course of its medical use remains unknown. This review provides a comprehensive understanding of W. somnifera, which will be useful for mechanism studies and potential medical applications of W. somnifera, as well as for the development of a rational quality control system for W. somnifera as a therapeutic material in the future.

Original languageEnglish
Article number1208
JournalMolecules
Volume28
Issue number3
DOIs
Publication statusPublished - Feb 2023
Externally publishedYes

Keywords

  • ashwagandha
  • botany
  • pharmacological and biological activity
  • phytochemistry
  • traditional use
  • Withania somnifera

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Biodiversity, Biochemical Profiling, and Pharmaco-Commercial Applications of Withania somnifera: A Review'. Together they form a unique fingerprint.

Cite this