Beneficial role of carica papaya extracts and phytochemicals on oxidative stress and related diseases: A mini review

Yew Rong Kong, Yong Xin Jong, Manisha Balakrishnan, Zhui Ken Bok, Janice Kwan Kah Weng, Kai Ching Tay, Bey Hing Goh, Yong Sze Ong, Kok Gan Chan, Learn Han Lee, Kooi Yeong Khaw

Research output: Journal PublicationReview articlepeer-review

38 Citations (Scopus)


Oxidative stress is a result of disruption in the balance between antioxidants and prooxidants in which subsequently impacting on redox signaling, causing cell and tissue damages. It leads to a range of medical conditions including inflammation, skin aging, impaired wound healing, chronic diseases and cancers but these conditions can be managed properly with the aid of antioxidants. This review features various studies to provide an overview on how Carica papaya help counteract oxidative stress via various mechanisms of action closely related to its antioxidant properties and eventually improving the management of various oxidative stress-related health conditions. Carica papaya is a topical plant species discovered to contain high amounts of natural antioxidants that can usually be found in their leaves, fruits and seeds. It contains various chemical compounds demonstrate significant antioxidant properties including caffeic acid, myricetin, rutin, quercetin, α-tocopherol, papain, benzyl isothiocyanate (BiTC), and kaempferol. Therefore, it can counteract pro-oxidants via a number of signaling pathways that either promote the expression of antioxidant enzymes or reduce ROS production. These signaling pathways activate the antioxidant defense mechanisms that protect the body against both intrinsic and extrinsic oxidative stress. To conclude, Carica papaya can be incorporated into medications or supplements to help manage the health conditions driven by oxidative stress and further studies are needed to investigate the potential of its chemical components to manage various chronic diseases.

Original languageEnglish
Article number287
Issue number4
Publication statusPublished - Apr 2021
Externally publishedYes


  • Aging
  • Alzheimer’s disease
  • Antioxidant
  • Cancer
  • Carica papaya
  • Diabetes
  • Inflammation
  • Oxidative stress
  • Periodontal disease
  • Wound healing

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology
  • General Immunology and Microbiology
  • General Agricultural and Biological Sciences


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