Basal expression of bradykinin B1 receptor in peripheral sensory ganglia in the rat

Qing Ping Ma, Ray Hill, Dalip Sirinathsinghji

Research output: Journal PublicationArticlepeer-review

47 Citations (Scopus)

Abstract

The bradykinin B1 receptor is thought to be induced by tissue injurY and inflammation. In the present study, we have investigated whether there is a basal expression of B1 receptor in dorsal root ganglion (DRG) and trigeminal ganglion neurons in rats. A substantial number of neurons in both DRGs and trigeminal ganglia were found to be B1-immunoreactive in rats. Both small and medium-sized DRG neurons were B1-immunoreactive, suggesting that they are likely to be Aδ- or C-fibre neurons which are involved in nociceptive transmission. These results support a possible role for B1 receptors in the modulation of nociceptive sensorY transmission.

Original languageEnglish
Pages (from-to)4003-4005
Number of pages3
JournalNeuroReport
Volume11
Issue number18
DOIs
Publication statusPublished - 2000
Externally publishedYes

Keywords

  • B receptor
  • B receptor knock-out
  • Bradykinin
  • Dorsal root ganglia (DRG)
  • Immunohistochemistry
  • Trigeminal nerve ganglia

ASJC Scopus subject areas

  • Neuroscience (all)

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