An Overview of the Bioactivities of Gedunin

Yong Sze Ong, Kooi Yeong Khaw, Loh Teng Hern Tan, Peng Nian Yew, Kai Boon Tan, Wei Hsum Yap, Siah Ying Tang, Liang Ee Low, Learn Han Lee, Bey Hing Goh

Research output: Chapter in Book/Conference proceedingBook Chapterpeer-review


Gedunin is a naturally occurring pentacyclic triterpenoid secondary metabolite presents in Meliaceae family. Since the first isolation and characterization of this compound at 1960s, the chemical synthesis and bioactive properties of this compound have been continuing researched. The plant has been historically used as the folk medicine to treat malaria and infectious diseases. Evidence-based pharmacology study showed that gedunin and its derivatives exerted enormous potential in the treatment of cancer, neurodegenerative and infectious diseases. Considering this year marks 60 years since the isolation of gedunin, this review presents an update of the bioactivity of gedunin and its derivatives with future prospect of this bioactive compound.

Original languageEnglish
Title of host publicationAdvanced Structured Materials
PublisherSpringer Science and Business Media Deutschland GmbH
Number of pages24
Publication statusPublished - 2021
Externally publishedYes

Publication series

NameAdvanced Structured Materials
ISSN (Print)1869-8433
ISSN (Electronic)1869-8441


  • Anti-cancer
  • Bioactivities
  • Gedunin
  • Pharmacology
  • Triterpenoid

ASJC Scopus subject areas

  • General Materials Science


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