Social networking sites (SNSs) have become new phenomena in social communication and interaction patterns which have profound impact in the way people communicate and connect with one another. The aim of this study is to test the advanced cognitive-behavioral model of generalized problematic Internet use (GPIU) in the context of Facebook use. The findings suggested that a preference for online social interaction and use of Facebook for mood regulation significantly explained the deficient self-regulation of Facebook use. Deficient self-regulation in turn showed great influence on and led to negative outcomes associating with the problematic Facebook use. Results indicated the data fit the model well and the variables in the current model accounted for 36 percent of the variance in mood regulation, 35 percent in respondents' deficient self-regulation, and 56 percent of variance explained in the negative outcomes. The findings provided important implications for both researchers and practitioners.