Alternansucrase as a key enabling tool of biotransformation from molecular features to applications: A review

Gang Chen, Imran Mahmood Khan, Tao Zhang, Osvaldo H. Campanella, Ming Miao

Research output: Journal PublicationReview articlepeer-review

Abstract

Alternansucrase (ASR), classified in GH70, produces unique α-glucans with alternating α-1,3 and α-1,6 glycosidic linkages in the backbone chain from renewable sucrose which is easily obtained from nature with low cost. ASR has synthesized many products with valuable functionalities that hold enormous commercial interest and promising applications. The influence of biocatalysis and fermentation parameters on the yields, and properties of products are critical for the propositions made to promote the enzyme application. Investigations on ASR have been compiled in the review to provide information on the enzyme, products and parameters. This review summarizes studies on the characteristics, conversion mechanism, products, and beneficial applications of ASR and exhibits structure-based technologies to improve enzyme activity, specificity, and thermostability for industrial applications. Finally, prospects for further development are also proposed for various ASR applications in food and other fields.

Original languageEnglish
Article number135096
JournalInternational Journal of Biological Macromolecules
Volume279
DOIs
Publication statusPublished - Nov 2024

Keywords

  • Alternansucrase
  • Applications
  • Molecular features

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Molecular Biology

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