Additive Manufacturing and Physicomechanical Characteristics of PEGDA Hydrogels: Recent Advances and Perspective for Tissue Engineering

Mohammad Hakim Khalili, Rujing Zhang, Sandra Wilson, Saurav Goel, Susan A. Impey, Adrianus Indrat Aria

Research output: Journal PublicationReview articlepeer-review

20 Citations (Scopus)

Abstract

In this brief review, we discuss the recent advancements in using poly(ethylene glycol) diacrylate (PEGDA) hydrogels for tissue engineering applications. PEGDA hydrogels are highly attractive in biomedical and biotechnology fields due to their soft and hydrated properties that can replicate living tissues. These hydrogels can be manipulated using light, heat, and cross-linkers to achieve desirable functionalities. Unlike previous reviews that focused solely on material design and fabrication of bioactive hydrogels and their cell viability and interactions with the extracellular matrix (ECM), we compare the traditional bulk photo-crosslinking method with the latest three-dimensional (3D) printing of PEGDA hydrogels. We present detailed evidence combining the physical, chemical, bulk, and localized mechanical characteristics, including their composition, fabrication methods, experimental conditions, and reported mechanical properties of bulk and 3D printed PEGDA hydrogels. Furthermore, we highlight the current state of biomedical applications of 3D PEGDA hydrogels in tissue engineering and organ-on-chip devices over the last 20 years. Finally, we delve into the current obstacles and future possibilities in the field of engineering 3D layer-by-layer (LbL) PEGDA hydrogels for tissue engineering and organ-on-chip devices.

Original languageEnglish
Article number2341
JournalPolymers
Volume15
Issue number10
DOIs
Publication statusPublished - May 2023
Externally publishedYes

Keywords

  • hydrogels
  • poly(ethylene glycol)diacrylate
  • printing
  • three-dimensional
  • tissue engineering

ASJC Scopus subject areas

  • General Chemistry
  • Polymers and Plastics

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