A survey on computer aided diagnosis for ocular diseases

Zhuo Zhang, Ruchir Srivastava, Huiying Liu, Xiangyu Chen, Lixin Duan, Damon Wing Kee Wong, Chee Keong Kwoh, Tien Yin Wong, Jiang Liu

Research output: Journal PublicationReview articlepeer-review

69 Citations (Scopus)


Method. We review ocular CAD methodologies for various data types. For each data type, we investigate the databases and the algorithms to detect different ocular diseases. Their advantages and shortcomings are analyzed and discussed.

Result: We have studied three types of data (i.e., clinical, genetic and imaging) that have been commonly used in existing methods for CAD. The recent developments in methods used in CAD of ocular diseases (such as Diabetic Retinopathy, Glaucoma, Age-related Macular Degeneration and Pathological Myopia) are investigated and summarized comprehensively.

Conclusion: While CAD for ocular diseases has shown considerable progress over the past years, the clinical importance of fully automatic CAD systems which are able to embed clinical knowledge and integrate heterogeneous data sources still show great potential for future breakthrough.

Background: Computer Aided Diagnosis (CAD), which can automate the detection process for ocular diseases, has attracted extensive attention from clinicians and researchers alike. It not only alleviates the burden on the clinicians by providing objective opinion with valuable insights, but also offers early detection and easy access for patients.

Original languageEnglish
Article number80
JournalBMC Medical Informatics and Decision Making
Issue number1
Publication statusPublished - 31 Aug 2014
Externally publishedYes


  • Clinical data
  • Computer Aided Diagnosis (CAD)
  • Genetic information
  • Ocular diseases
  • Ocular imaging
  • Review

ASJC Scopus subject areas

  • Health Policy
  • Health Informatics
  • Computer Science Applications


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