A sensitive fluorescent assay based on gold-nanoclusters coated on molecularly imprinted covalent organic frameworks and its application in malachite green detection

Lehan Zhao, Xianfeng Lin, Nuo Duan, Imran Mahmood Khan, Zhouping Wang, Shijia Wu

Research output: Journal PublicationArticlepeer-review

11 Citations (Scopus)

Abstract

Malachite green (MG), as a parasiticide, is widely used in aquaculture to increase the production of the fishery industry. It poses a great danger to both the food system and the human body. In this study, a one-pot reverse microemulsion polymerization was employed to combine the gold nanoclusters (AuNCs) with molecularly imprinted polymers (MIPs) and covalent organic frameworks (COFs) to synthesize an efficient fluorescent hybrid probe (AuNCs@COFs@MIPs) for selective detection of MG. The specific recognition of AuNCs@COFs@MIPs towards MG triggers the fluorescence quenching of AuNCs. The fluorescent response was linearly related to the concentration over the range of 10–150 nmol/L with a limit of detection of 2.78 nmol/L. In addition, the proposed probe was further applied to fish and water samples. A favorable recovery ranged from 97.34 to 101.51 % toward trace amounts of MG indicating its promising application for detecting residue of veterinary drugs.

Original languageEnglish
Article number135425
JournalFood Chemistry
Volume410
DOIs
Publication statusPublished - 1 Jun 2023
Externally publishedYes

Keywords

  • Covalent organic frameworks
  • Fluorescent assay
  • Gold nanoclusters
  • Malachite green
  • Molecularly imprinted polymers

ASJC Scopus subject areas

  • Analytical Chemistry
  • Food Science

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