A packed-column supercritical fluid chromatographic (SFC) separation of explosive compounds hyphenated to atmospheric pressure chemical ionisation (APCI) mass spectrometric (MS) detection has been developed. Nitroaromatics, nitramines and nitrate esters can be resolved and identified, with theoretical limits of detection of approximately 100 ng on column. This represents a development over previously described gas chromatography-thermal energy analysis (GC-TEA), gas chromatography- electron capture detection (GC-ECD) and SFC methods for the analysis of explosives due to the molecular identification afforded by the mass spectrometry. Explosives in the combinations expected in commercially available mixtures can be separated and identified. A successful application to a laboratory trial simulating casework is described. Copyright (C) 1999 Elsevier Science Ireland Ltd.
- Atmospheric-pressure chemical-ionisation-mass spectrometry
- Nitrate esters
- Supercritical fluid chromatography
ASJC Scopus subject areas
- Pathology and Forensic Medicine