A focus on the human lens in vitro

I. Michael Wormstone, David J. Collison, Simon P. Hansom, George Duncan

Research output: Journal PublicationArticlepeer-review

33 Citations (Scopus)

Abstract

The lens is a unique organ in that it is avascular and non-innervated, obtaining all nutrients from the aqueous and vitreous humours that bathe the lens. All lenses attempt to achieve the same goal, namely to maintain transparency and focus light on to the retina. However, the mechanisms by which these processes are maintained, or disrupted leading to a loss of transparency, are likely to differ in some cases between animals and humans. To allow comparison to take place, human in vitro models have been developed, ranging from whole organ culture to the generation of human lens cell lines. All have their merits and limitations, but as a whole, they permit extensive studies of lens cell behaviour and function to be carried out. Together, these in vitro methods allow the biological events of the lens to be further understood. Moreover, they could help identify the mechanisms that give rise to cataract and posterior capsule opacification, a problem that occurs following surgery, providing therapeutic targets for their prevention.

Original languageEnglish
Pages (from-to)215-221
Number of pages7
JournalEnvironmental Toxicology and Pharmacology
Volume21
Issue number2 SPEC. ISS.
DOIs
Publication statusPublished - Feb 2006
Externally publishedYes

Keywords

  • Cataract
  • Culture
  • Human
  • In vitro
  • Lens
  • Posterior capsule opacification

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Health, Toxicology and Mutagenesis

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