2022 Chinese national clinical practice guideline on Helicobacter pylori eradication treatment

Liya Zhou, Hong Lu, Zhiqiang Song, Bin Lyu, Ye Chen, Jiyao Wang, Jun Xia, Zhan Zhao, Yuanyuan Ji

Research output: Journal PublicationArticlepeer-review

27 Citations (Scopus)


Background:Helicobacter pylori (H. pylori) infection is an infectious disease with a prevalence rate of up to 50% worldwide. It can cause indigestion, gastritis, peptic ulcer, and gastric cancer. H. pylori eradication treatment can effectively control disease progression and reduce the risk of the above conditions. However, the escalating trend of antibiotic resistance presents a global challenge for H. pylori eradication. We aim to provide guidance on pharmacological treatment of H. pylori infection.Methods:This clinical practice guideline is developed following the World Health Organization's recommended process, adopting Grading of Recommendations Assessment, Development and Evaluation in assessing evidence quality, and utilizing Evidence to Decision framework to formulate clinical recommendations, minimizing bias and increasing transparency of the clinical practice guideline development process. We used the Reporting Items for practice Guidelines in HealThcare (RIGHT) statement and The Appraisal of Guidelines for Research and Evaluation II (AGREE II) as reporting and conduct guides to ensure the guideline's completeness and transparency.Results:Though decreasing in developed countries, the prevalence of H. pylori remains high in developing countries, causing a major public health burden. This clinical practice guideline contains 12 recommendations concerning pharmacological treatment for H. pylori eradication. Among them, it is worth highlighting that bismuth preparations are inexpensive, safe, and effective, consequently making bismuth quadruple therapy a preferred choice for initial and rescue treatment. In empirical treatment, high-dose dual therapy is equally effective compared with bismuth quadruple therapy.Conclusions:The 12 recommendations in this clinical practice guideline are formed with consideration for stakeholders' values and preferences, resource use, feasibility, and acceptability. Recommendations are generalizable to resource limited settings with similar antibiotic resistance pattern as China, and lower middle-income countries facing comparable sociological and technical challenges.Registration:Guidelines International Network (GIN) website, https://guidelines.ebmportal.com/node/69996.

Original languageEnglish
Pages (from-to)2899-2910
Number of pages12
JournalChinese Medical Journal
Issue number24
Publication statusPublished - 20 Dec 2022


  • Guideline
  • Helicobacter pylori
  • Peptic ulcer
  • Pharmacological treatment

ASJC Scopus subject areas

  • General Medicine


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