Abstract
Background: The intermediate filament protein, nestin, may play a role in tissue regeneration and nestin expression has been detected in coronary atherosclerotic plaques. To date, no population-based studies concerning the role of the nestin gene in coronary heart disease (CHD) have been reported. Methods and Results: The 3 SNPs in the nestin gene were genotyped in 1,494 individuals from 580 Irish families. rs11582300 and rs3748570 were associated with early-onset CHD (p=0.04 and p=0.02). Conclusion: Nestin gene variants are associated with early-onset CHD. Further research on nestin's role in atherosclerosis is required.
| Original language | English |
|---|---|
| Pages (from-to) | 1538-1539 |
| Number of pages | 2 |
| Journal | Circulation Journal |
| Volume | 72 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2008 |
| Externally published | Yes |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Free Keywords
- Coronary heart disease
- Nestin
- Polymorphism
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
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