Total synthesis of (+)-intricarene using a biogenetically patterned pathway from (-)-bipinnatin J, involving a novel transannular [5+2] (1,3-dipolar) cycloaddition

Keyphrases

• Total Synthesis 100%
• Transannular 100%
• 1,3-dipolar Cycloaddition 100%
• Acetonitrile 50%
• Singlet Oxygen 50%
• Acetylation 50%
• Butenolide 50%
• Hiyama 50%
• Asymmetric Synthesis 50%
• VO(acac)2 50%
• Oxidopyrylium 50%
• Tautomeric Forms 50%
• Stille Coupling 50%
• Hydroxypyrones 50%
• Chiral Lactones 50%
• Macrocyclic Diterpenes 50%
• Glycidol 50%
• Enzyme System 50%
• Vinyl Iodide 50%
• Gorgonian Octocoral 50%
• Cytochrome P450 Monooxygenase 50%
• Allylation Reaction 50%

Chemistry

• 1,3-cycloaddition 100%
• Acetonitrile 50%
• Lactone 50%
• Allylation 50%
• Nozaki-Hiyama Reaction 50%
• Butenolide 50%
• Diterpene 50%
• Acetylation 50%
• Asymmetric Synthesis 50%
• Glycidol 50%
• Stille Coupling Reaction 50%
• Monooxygenase 50%