Synthesis of antimalarial trioxanes via continuous photo-oxidation with 1O2 in supercritical CO2

Jessica F.B. Hall; Richard A. Bourne; Xue Han; James H. Earley; Martyn Poliakoff; Michael W. George

doi:10.1039/c2gc36711d

Synthesis of antimalarial trioxanes via continuous photo-oxidation with ¹O₂ in supercritical CO₂

Jessica F.B. Hall
, Richard A. Bourne
, Xue Han
, James H. Earley
, Martyn Poliakoff^*
, Michael W. George

^*Corresponding author for this work

Research output: Journal Publication › Article › peer-review

35 Citations (Scopus)

Abstract

The oxidation of an allylic alcohol to its hydroperoxides represents a key step in the synthesis of a series of spirobicyclic, antimalarial trioxanes. Herein, we investigate the continuous photo-oxidation of an allylic alcohol with ¹O₂ in scCO₂, as a 'green' alternative to conventional methods, and examine the remaining two steps in the synthesis of antimalarial trioxanes from readily available starting materials.

Original language	English
Pages (from-to)	177-180
Number of pages	4
Journal	Green Chemistry
Volume	15
Issue number	1
DOIs	https://doi.org/10.1039/c2gc36711d
Publication status	Published - Jan 2013
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Environmental Chemistry
Pollution

Access to Document

10.1039/c2gc36711d

Cite this

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abstract = "The oxidation of an allylic alcohol to its hydroperoxides represents a key step in the synthesis of a series of spirobicyclic, antimalarial trioxanes. Herein, we investigate the continuous photo-oxidation of an allylic alcohol with 1O2 in scCO2, as a 'green' alternative to conventional methods, and examine the remaining two steps in the synthesis of antimalarial trioxanes from readily available starting materials.",

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AU - Poliakoff, Martyn

AU - George, Michael W.

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AB - The oxidation of an allylic alcohol to its hydroperoxides represents a key step in the synthesis of a series of spirobicyclic, antimalarial trioxanes. Herein, we investigate the continuous photo-oxidation of an allylic alcohol with 1O2 in scCO2, as a 'green' alternative to conventional methods, and examine the remaining two steps in the synthesis of antimalarial trioxanes from readily available starting materials.

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