Streamlining Crystallization Process Design

Solid/liquid phase equilibrium (SLE) phase diagrams have been used to develop a reliable crystallization process. The use of phase diagrams to represent the phase behaviors of various systems allows the identification of regions or ranges of compositions where a pure solid or a mixture of solids can be obtained using crystallization. The synthetic or stationary method and differential scanning calorimetry (DSC) have been used to experimentally determine SLE. The combination of experimentation and modeling on SLE has been found promising in the development of process alternatives demanding lower costs and less time.