Sertraline racemate and enantiomer: Solid-state characterization, binary phase diagram, and crystal structures

Quan He; Sohrab Rohani; Jesse Zhu; Hassan Gomaa

doi:10.1021/cg901197b

Sertraline racemate and enantiomer: Solid-state characterization, binary phase diagram, and crystal structures

Quan He
, Sohrab Rohani
, Jesse Zhu
, Hassan Gomaa

Research output: Journal Publication › Article › peer-review

11 Citations (Scopus)

Abstract

The racemate and enantiomer of sertraline free base were prepared and characterized. The crystalline sertraline enantiomer is relatively less polymorphic compared with the sertraline-HCl salt. The solid-state nature of sertraline racemate was identified to be a racemic compound through a binary melting point phase diagram and spectroscopy analysis. The crystal structures of the racemate and enantiomer were determined to be monoclinic P12₁/n1 and P2₁, respectively.

Original language	English
Pages (from-to)	1633-1645
Number of pages	13
Journal	Crystal Growth and Design
Volume	10
Issue number	4
DOIs	https://doi.org/10.1021/cg901197b
Publication status	Published - 7 Apr 2010
Externally published	Yes

ASJC Scopus subject areas

General Chemistry
General Materials Science
Condensed Matter Physics

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10.1021/cg901197b

Cite this

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abstract = "The racemate and enantiomer of sertraline free base were prepared and characterized. The crystalline sertraline enantiomer is relatively less polymorphic compared with the sertraline-HCl salt. The solid-state nature of sertraline racemate was identified to be a racemic compound through a binary melting point phase diagram and spectroscopy analysis. The crystal structures of the racemate and enantiomer were determined to be monoclinic P121/n1 and P21, respectively.",

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AU - He, Quan

AU - Rohani, Sohrab

AU - Zhu, Jesse

AU - Gomaa, Hassan

PY - 2010/4/7

Y1 - 2010/4/7

N2 - The racemate and enantiomer of sertraline free base were prepared and characterized. The crystalline sertraline enantiomer is relatively less polymorphic compared with the sertraline-HCl salt. The solid-state nature of sertraline racemate was identified to be a racemic compound through a binary melting point phase diagram and spectroscopy analysis. The crystal structures of the racemate and enantiomer were determined to be monoclinic P121/n1 and P21, respectively.

AB - The racemate and enantiomer of sertraline free base were prepared and characterized. The crystalline sertraline enantiomer is relatively less polymorphic compared with the sertraline-HCl salt. The solid-state nature of sertraline racemate was identified to be a racemic compound through a binary melting point phase diagram and spectroscopy analysis. The crystal structures of the racemate and enantiomer were determined to be monoclinic P121/n1 and P21, respectively.

UR - https://www.scopus.com/pages/publications/77950844784

U2 - 10.1021/cg901197b

DO - 10.1021/cg901197b

M3 - Article

AN - SCOPUS:77950844784

SN - 1528-7483

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JO - Crystal Growth and Design

JF - Crystal Growth and Design

IS - 4

ER -

Sertraline racemate and enantiomer: Solid-state characterization, binary phase diagram, and crystal structures

Abstract

ASJC Scopus subject areas

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