Remarks on KS models describing cell aggregation with obstacle interference

Cells encounter a diverse array of physical and chemical signals as they navigate their natural surroundings. However, their response to the simultaneous presence of multiple cues remains elusive. Particularly, the impact of topography alongside a chemotactic gradient on cell migratory behavior remains insufficiently explored. In this paper, we investigate the effects of topographical obstacles during chemotaxis. Our approach involves modifying the Keller-Segel model, incorporating a spatially dependent coefficient of chemotaxis. Through our analysis, we demonstrate that this coefficient plays a crucial role in preventing blow-up phenomena in cell concentration.