Abstract
Cataract (a clouding of the lens) renders tens of millions blind. The only method currently employed to treat cataract is surgery and an artificial intraocular lens (IOL) implant. However, secondary visual loss occurs in millions of patients due to a wound-healing response that results in a condition known as posterior capsule opacification (PCO). This can take the form of fibrotic PCO (cell growth, EMT, matrix deposition, matrix contraction) and regenerative PCO (aberrant fiber cell differentiation). In this article we will discuss the regulatory factors driving PCO and explore surgical and therapeutic developments for PCO management.
| Original language | English |
|---|---|
| Title of host publication | Encyclopedia of the Eye |
| Editors | Patricia D’Amore |
| Publisher | Elsevier |
| Pages | V1:528-V1:537 |
| Edition | 2nd |
| ISBN (Electronic) | 9780443138201 |
| ISBN (Print) | 9780443138393 |
| DOIs | |
| Publication status | Published - Jun 2025 |
Free Keywords
- Cataract surgery
- Differentiation
- EMT
- Fibrosis
- Intraocular lens
- Matrix contraction
- Migration
- Posterior capsule opacification
- Proliferation
- Wound-healing
ASJC Scopus subject areas
- General Medicine
- General Neuroscience
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