Nickel-catalyzed regioselective hydrogen isotope exchange accelerated by 2-pyridones

Zhi Jiang Jiang; Si Han Xu; Yuhang Su; Erxun Hu; Jiawei Han; Jian Fei Bai; Bencan Tang; Jia Chen; Zhanghua Gao

doi:10.1039/d3cc05257e

Nickel-catalyzed regioselective hydrogen isotope exchange accelerated by 2-pyridones

Zhi Jiang Jiang
, Si Han Xu
, Yuhang Su
, Erxun Hu
, Jiawei Han
, Jian Fei Bai
, Bencan Tang
, Jia Chen
, Zhanghua Gao

Research output: Journal Publication › Article › peer-review

12 Citations (Scopus)

Abstract

A nickel-catalyzed hydrogen isotope exchange has been developed with acetone-d₆ as the deuterium source. The reaction showed an improved kinetic feature of H/D exchange under the assistance of 2-pyridones, efficiently affording regioselective labeled aryl and alkyl carboxamides.

Original language	English
Pages (from-to)	384-387
Number of pages	4
Journal	Chemical Communications
Volume	60
Issue number	4
DOIs	https://doi.org/10.1039/d3cc05257e
Publication status	Published - 27 Nov 2023

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Catalysis
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/d3cc05257e

Cite this

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title = "Nickel-catalyzed regioselective hydrogen isotope exchange accelerated by 2-pyridones",

abstract = "A nickel-catalyzed hydrogen isotope exchange has been developed with acetone-d6 as the deuterium source. The reaction showed an improved kinetic feature of H/D exchange under the assistance of 2-pyridones, efficiently affording regioselective labeled aryl and alkyl carboxamides.",

author = "Jiang, \{Zhi Jiang\} and Xu, \{Si Han\} and Yuhang Su and Erxun Hu and Jiawei Han and Bai, \{Jian Fei\} and Bencan Tang and Jia Chen and Zhanghua Gao",

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year = "2023",

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doi = "10.1039/d3cc05257e",

language = "English",

volume = "60",

pages = "384--387",

journal = "Chemical Communications",

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publisher = "Royal Society of Chemistry",

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T1 - Nickel-catalyzed regioselective hydrogen isotope exchange accelerated by 2-pyridones

AU - Jiang, Zhi Jiang

AU - Xu, Si Han

AU - Su, Yuhang

AU - Hu, Erxun

AU - Han, Jiawei

AU - Bai, Jian Fei

AU - Tang, Bencan

AU - Chen, Jia

AU - Gao, Zhanghua

PY - 2023/11/27

Y1 - 2023/11/27

N2 - A nickel-catalyzed hydrogen isotope exchange has been developed with acetone-d6 as the deuterium source. The reaction showed an improved kinetic feature of H/D exchange under the assistance of 2-pyridones, efficiently affording regioselective labeled aryl and alkyl carboxamides.

AB - A nickel-catalyzed hydrogen isotope exchange has been developed with acetone-d6 as the deuterium source. The reaction showed an improved kinetic feature of H/D exchange under the assistance of 2-pyridones, efficiently affording regioselective labeled aryl and alkyl carboxamides.

UR - https://www.scopus.com/pages/publications/85179607291

U2 - 10.1039/d3cc05257e

DO - 10.1039/d3cc05257e

M3 - Article

C2 - 38063024

AN - SCOPUS:85179607291

SN - 1359-7345

VL - 60

SP - 384

EP - 387

JO - Chemical Communications

JF - Chemical Communications

IS - 4

ER -

Nickel-catalyzed regioselective hydrogen isotope exchange accelerated by 2-pyridones

Abstract

ASJC Scopus subject areas

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