Integrated Selection of Coformers, Solvents, and Operating Conditions for Optimal Process and Product Performance of Pharmaceutical Cocrystals

Keyphrases

• Operating Conditions 100%
• Process Performance 100%
• Product Performance 100%
• Cocrystal 100%
• Pharmaceutical Cocrystal 100%
• Solvent Conditions 100%
• Active Pharmaceutical Ingredients 60%
• Solution Strategies 40%
• Performance Optimization 20%
• Dynamic Model 20%
• Design Process 20%
• Optimization Problem 20%
• Performance Prediction 20%
• Design Decisions 20%
• Process Efficiency 20%
• Product Design 20%
• Optimization Framework 20%
• Performance Criteria 20%
• Impact-based 20%
• Programming Solution 20%
• Mixed Integer Nonlinear Programming 20%
• Model Optimization 20%
• Perturbed-chain Statistical Associating Fluid Theory (PC-SAFT) 20%
• Mapping Approach 20%
• Medium Composition 20%
• Crystallization Process 20%
• Branch-and-bound 20%
• Mixed-integer Nonlinear Problem 20%
• Low Water Solubility 20%
• High Solubility 20%
• Feeding Strategy 20%
• Competitive Products 20%
• Competition Process 20%
• Dissolution Media 20%
• Equilibrium Processes 20%
• Sustainable Yield 20%
• Dissolution Behavior 20%
• Co-crystallization 20%
• Process Optimization Approach 20%
• Condition Selection 20%
• Enhanced Bioavailability 20%
• Solution Crystallization 20%
• Nonlinear Programming Problem 20%
• Continuous Mapping 20%
• Rotating Disk Apparatus 20%

Engineering

• Process Performance 100%
• Product Performance 100%
• Dynamic Models 33%
• Early Stage 33%
• Limitations 33%
• Optimisation Problem 33%
• Optimization Approach 33%
• Product Design 33%
• Performance Criterion 33%
• Process Design 33%
• Rotating Disk 33%
• Competing Process 33%
• Equilibrium Process 33%