Identification and characterization of solid-state nature of 2-chloromandelic acid

Quan He; Jesse Zhu; Hassan Gomaa; Michael Jennings; Sohrab Rohani

doi:10.1002/jps.21560

Identification and characterization of solid-state nature of 2-chloromandelic acid

Quan He
, Jesse Zhu
, Hassan Gomaa
, Michael Jennings
, Sohrab Rohani^*

^*Corresponding author for this work

Research output: Journal Publication › Article › peer-review

20 Citations (Scopus)

Abstract

The racemate and enantiomers of 2-chloromandelic acid were characterized by SS-NMR, XRPD, and FTIR. The binary melting point phase diagram was constructed by DSC (differential scanning calorimetry). The solid-state nature of 2-chloromandelic acid was identified to be a racemic compound. The crystal structure of racemic compound was determined to be monoclinic P2₁/c.

Original language	English
Pages (from-to)	1835-1844
Number of pages	10
Journal	Journal of Pharmaceutical Sciences
Volume	98
Issue number	5
DOIs	https://doi.org/10.1002/jps.21560
Publication status	Published - May 2009
Externally published	Yes

Free Keywords

2-chloromandelic acid
Conglomerate
Crystal structure
Differential scanning calorimetry
Enantiomer
Melting point diagram
Racemate

ASJC Scopus subject areas

Pharmaceutical Science

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10.1002/jps.21560

Cite this

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title = "Identification and characterization of solid-state nature of 2-chloromandelic acid",

abstract = "The racemate and enantiomers of 2-chloromandelic acid were characterized by SS-NMR, XRPD, and FTIR. The binary melting point phase diagram was constructed by DSC (differential scanning calorimetry). The solid-state nature of 2-chloromandelic acid was identified to be a racemic compound. The crystal structure of racemic compound was determined to be monoclinic P21/c.",

keywords = "2-chloromandelic acid, Conglomerate, Crystal structure, Differential scanning calorimetry, Enantiomer, Melting point diagram, Racemate",

author = "Quan He and Jesse Zhu and Hassan Gomaa and Michael Jennings and Sohrab Rohani",

year = "2009",

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language = "English",

volume = "98",

pages = "1835--1844",

journal = "Journal of Pharmaceutical Sciences",

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T1 - Identification and characterization of solid-state nature of 2-chloromandelic acid

AU - He, Quan

AU - Zhu, Jesse

AU - Gomaa, Hassan

AU - Jennings, Michael

AU - Rohani, Sohrab

PY - 2009/5

Y1 - 2009/5

N2 - The racemate and enantiomers of 2-chloromandelic acid were characterized by SS-NMR, XRPD, and FTIR. The binary melting point phase diagram was constructed by DSC (differential scanning calorimetry). The solid-state nature of 2-chloromandelic acid was identified to be a racemic compound. The crystal structure of racemic compound was determined to be monoclinic P21/c.

AB - The racemate and enantiomers of 2-chloromandelic acid were characterized by SS-NMR, XRPD, and FTIR. The binary melting point phase diagram was constructed by DSC (differential scanning calorimetry). The solid-state nature of 2-chloromandelic acid was identified to be a racemic compound. The crystal structure of racemic compound was determined to be monoclinic P21/c.

KW - 2-chloromandelic acid

KW - Conglomerate

KW - Crystal structure

KW - Differential scanning calorimetry

KW - Enantiomer

KW - Melting point diagram

KW - Racemate

UR - https://www.scopus.com/pages/publications/65949093281

U2 - 10.1002/jps.21560

DO - 10.1002/jps.21560

M3 - Article

C2 - 18837015

AN - SCOPUS:65949093281

SN - 0022-3549

VL - 98

SP - 1835

EP - 1844

JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

IS - 5

ER -

Identification and characterization of solid-state nature of 2-chloromandelic acid

Abstract

Free Keywords

ASJC Scopus subject areas

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