TY - JOUR
T1 - Heliaquanoids A-E, Five Sesquiterpenoid Dimers from Inula helianthus-aquatica
AU - Zheng, Zai Qin
AU - Wei, Wen Jun
AU - Zhang, Junmin
AU - Li, Hang Ying
AU - Xu, Kai
AU - Xu, Jiayuan
AU - Tang, Bencan
AU - Li, Ya
AU - Gao, Kun
N1 - Publisher Copyright:
© 2019 American Chemical Society.
PY - 2019/4/5
Y1 - 2019/4/5
N2 - Heliaquanoid A (1), the first exo-2,4-linked Diels-Alder adduct between a pseudoguaianolide dienophile and a guaianolide diene, and heliaquanoids B-E (2-5), four new 2,4-linked Diels-Alder adducts between a xanthanolide dienophile and a guaianolide diene, were isolated from stems and leaves of Inula helianthus-aquatica. Their structures were determined by NMR spectroscopy, a modified Mosher's method, electronic circular dichroism, and X-ray diffraction analysis. Compounds 2 and 3 exhibited moderate cytotoxic activities against HL-60 cells with IC50 values of 7.5 and 4.9 μM, respectively.
AB - Heliaquanoid A (1), the first exo-2,4-linked Diels-Alder adduct between a pseudoguaianolide dienophile and a guaianolide diene, and heliaquanoids B-E (2-5), four new 2,4-linked Diels-Alder adducts between a xanthanolide dienophile and a guaianolide diene, were isolated from stems and leaves of Inula helianthus-aquatica. Their structures were determined by NMR spectroscopy, a modified Mosher's method, electronic circular dichroism, and X-ray diffraction analysis. Compounds 2 and 3 exhibited moderate cytotoxic activities against HL-60 cells with IC50 values of 7.5 and 4.9 μM, respectively.
UR - https://www.scopus.com/pages/publications/85063945782
U2 - 10.1021/acs.joc.8b03284
DO - 10.1021/acs.joc.8b03284
M3 - Article
C2 - 30882223
AN - SCOPUS:85063945782
SN - 0022-3263
VL - 84
SP - 4473
EP - 4477
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
IS - 7
ER -