Genome sequence of Streptomyces pluripotens MUSC 135T exhibiting antibacterial and antioxidant activity

Hooi Leng Ser; Wen Si Tan; Nurul Syakima Ab Mutalib; Huey Jia Cheng; Wai Fong Yin; Kok Gan Chan; Learn Han Lee

doi:10.1016/j.margen.2015.09.010

Genome sequence of Streptomyces pluripotens MUSC 135^T exhibiting antibacterial and antioxidant activity

Hooi Leng Ser
, Wen Si Tan
, Nurul Syakima Ab Mutalib
, Huey Jia Cheng
, Wai Fong Yin
, Kok Gan Chan
, Learn Han Lee^*

^*Corresponding author for this work

Research output: Journal Publication › Article › peer-review

27 Citations (Scopus)

Abstract

Isolated from intertidal soil, Streptomyces pluripotens MUSC 135^T produces a broad-spectrum bacteriocin against the pathogens methicillin-resistant Staphylococcus aureus (MRSA) ATCC BAA-44^T, Salmonella typhi ATCC 19430^T and Aeromonas hydrophila ATCC 7966^T. Along with antibacterial activity, fermentation studies on strain MUSC 135^T revealed production of antioxidant(s). The high quality draft genome of MUSC 135^T comprises 7,480,269bp with G+C content of 70.00%. Through bioinformatics analysis, 72 gene clusters identified in the genome were associated with the production of secondary metabolites, which may shed light on the identity of these bioactive compounds.

Original language	English
Pages (from-to)	281-283
Number of pages	3
Journal	Marine Genomics
Volume	24
DOIs	https://doi.org/10.1016/j.margen.2015.09.010
Publication status	Published - 1 Dec 2015
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Free Keywords

Bacteriocin
Genome
MRSA
Methycillin-resistant Staphylococcus aureus
Streptomyces pluripotens

ASJC Scopus subject areas

Aquatic Science
Genetics

Access to Document

10.1016/j.margen.2015.09.010

Cite this

@article{59af3049156a4a099ad88dac0c6c8937,

title = "Genome sequence of Streptomyces pluripotens MUSC 135T exhibiting antibacterial and antioxidant activity",

abstract = "Isolated from intertidal soil, Streptomyces pluripotens MUSC 135T produces a broad-spectrum bacteriocin against the pathogens methicillin-resistant Staphylococcus aureus (MRSA) ATCC BAA-44T, Salmonella typhi ATCC 19430T and Aeromonas hydrophila ATCC 7966T. Along with antibacterial activity, fermentation studies on strain MUSC 135T revealed production of antioxidant(s). The high quality draft genome of MUSC 135T comprises 7,480,269bp with G+C content of 70.00\%. Through bioinformatics analysis, 72 gene clusters identified in the genome were associated with the production of secondary metabolites, which may shed light on the identity of these bioactive compounds.",

keywords = "Bacteriocin, Genome, MRSA, Methycillin-resistant Staphylococcus aureus, Streptomyces pluripotens",

author = "Ser, \{Hooi Leng\} and Tan, \{Wen Si\} and \{Ab Mutalib\}, \{Nurul Syakima\} and Cheng, \{Huey Jia\} and Yin, \{Wai Fong\} and Chan, \{Kok Gan\} and Lee, \{Learn Han\}",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier B.V.",

year = "2015",

month = dec,

day = "1",

doi = "10.1016/j.margen.2015.09.010",

language = "English",

volume = "24",

pages = "281--283",

journal = "Marine Genomics",

issn = "1874-7787",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Genome sequence of Streptomyces pluripotens MUSC 135T exhibiting antibacterial and antioxidant activity

AU - Ser, Hooi Leng

AU - Tan, Wen Si

AU - Ab Mutalib, Nurul Syakima

AU - Cheng, Huey Jia

AU - Yin, Wai Fong

AU - Chan, Kok Gan

AU - Lee, Learn Han

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Isolated from intertidal soil, Streptomyces pluripotens MUSC 135T produces a broad-spectrum bacteriocin against the pathogens methicillin-resistant Staphylococcus aureus (MRSA) ATCC BAA-44T, Salmonella typhi ATCC 19430T and Aeromonas hydrophila ATCC 7966T. Along with antibacterial activity, fermentation studies on strain MUSC 135T revealed production of antioxidant(s). The high quality draft genome of MUSC 135T comprises 7,480,269bp with G+C content of 70.00%. Through bioinformatics analysis, 72 gene clusters identified in the genome were associated with the production of secondary metabolites, which may shed light on the identity of these bioactive compounds.

AB - Isolated from intertidal soil, Streptomyces pluripotens MUSC 135T produces a broad-spectrum bacteriocin against the pathogens methicillin-resistant Staphylococcus aureus (MRSA) ATCC BAA-44T, Salmonella typhi ATCC 19430T and Aeromonas hydrophila ATCC 7966T. Along with antibacterial activity, fermentation studies on strain MUSC 135T revealed production of antioxidant(s). The high quality draft genome of MUSC 135T comprises 7,480,269bp with G+C content of 70.00%. Through bioinformatics analysis, 72 gene clusters identified in the genome were associated with the production of secondary metabolites, which may shed light on the identity of these bioactive compounds.

KW - Bacteriocin

KW - Genome

KW - MRSA

KW - Methycillin-resistant Staphylococcus aureus

KW - Streptomyces pluripotens

UR - https://www.scopus.com/pages/publications/84950972396

U2 - 10.1016/j.margen.2015.09.010

DO - 10.1016/j.margen.2015.09.010

M3 - Article

C2 - 26452302

AN - SCOPUS:84950972396

SN - 1874-7787

VL - 24

SP - 281

EP - 283

JO - Marine Genomics

JF - Marine Genomics

ER -