TY - JOUR
T1 - General practice chest X-ray rate is associated with earlier lung cancer diagnosis and reduced all-cause mortality
T2 - a retrospective observational study
AU - Bradley, Stephen H.
AU - Neal, Richard D.
AU - Callister, Matthew E.J.
AU - Cornwell, Benjamin
AU - Hamilton, William T.
AU - Abel, Gary A.
AU - Shinkins, Bethany
AU - Hubbard, Richard B.
AU - Barclay, Matthew E.
N1 - Publisher Copyright:
©The Authors.
PY - 2025/5
Y1 - 2025/5
N2 - Background Evidence is equivocal on whether general practice rates of investigation in symptomatic patients using chest X-ray (CXR) affect outcomes. Aim To determine whether there is an association between rates of CXR requested in general practice and lung cancer outcomes. Design and setting Observational study using data on English general practices. Method Cancer registry data for patients diagnosed with lung cancer in 2014–2018 were linked to data on general practice CXRs from 2013 until 2017. Cancer stage at diagnosis (I/II versus III/IV) and 1-year and 5-year survival rates (conditional on survival to 1 year) post-diagnosis were reported by general practice quintile of CXR rate, with adjustment for population differences (age, smoking, prevalence of chronic obstructive pulmonary disease and heart failure, ethnicity, and deprivation) and by unadjusted category (low, medium, and high). Results In total, 192 631 patient records and CXR rates for 7409 practices were obtained. Practices in the highest quintile of CXR rate had fewer cancers diagnosed at stage III/IV compared with those in the lowest quintile (odds ratio [OR] 0.87, 95% confidence interval [CI] = 0.83 to 0.92, P<0.001). The association was weaker for the high unadjusted CXR category (OR 0.94, 95% CI = 0.91 to 0.97). For the highest adjusted quintile, hazard ratios (HRs) for death within 1 year and 5 years were 0.92 (95% CI = 0.90 to 0.95, P<0.001) and 0.95 (95% CI = 0.91 to 0.99, P = 0.023), respectively. For the high unadjusted CXR category, the HR for 1-year survival was 0.98 (95% CI = 0.96 to 0.99, P = 0.004), with no association demonstrated for 5-year survival. Conclusion Patients registered at general practices with higher CXR use have a favourable stage distribution and slightly better survival. This supports the use of CXR in promoting earlier diagnosis of symptomatic lung cancer in general practice.
AB - Background Evidence is equivocal on whether general practice rates of investigation in symptomatic patients using chest X-ray (CXR) affect outcomes. Aim To determine whether there is an association between rates of CXR requested in general practice and lung cancer outcomes. Design and setting Observational study using data on English general practices. Method Cancer registry data for patients diagnosed with lung cancer in 2014–2018 were linked to data on general practice CXRs from 2013 until 2017. Cancer stage at diagnosis (I/II versus III/IV) and 1-year and 5-year survival rates (conditional on survival to 1 year) post-diagnosis were reported by general practice quintile of CXR rate, with adjustment for population differences (age, smoking, prevalence of chronic obstructive pulmonary disease and heart failure, ethnicity, and deprivation) and by unadjusted category (low, medium, and high). Results In total, 192 631 patient records and CXR rates for 7409 practices were obtained. Practices in the highest quintile of CXR rate had fewer cancers diagnosed at stage III/IV compared with those in the lowest quintile (odds ratio [OR] 0.87, 95% confidence interval [CI] = 0.83 to 0.92, P<0.001). The association was weaker for the high unadjusted CXR category (OR 0.94, 95% CI = 0.91 to 0.97). For the highest adjusted quintile, hazard ratios (HRs) for death within 1 year and 5 years were 0.92 (95% CI = 0.90 to 0.95, P<0.001) and 0.95 (95% CI = 0.91 to 0.99, P = 0.023), respectively. For the high unadjusted CXR category, the HR for 1-year survival was 0.98 (95% CI = 0.96 to 0.99, P = 0.004), with no association demonstrated for 5-year survival. Conclusion Patients registered at general practices with higher CXR use have a favourable stage distribution and slightly better survival. This supports the use of CXR in promoting earlier diagnosis of symptomatic lung cancer in general practice.
KW - chest X-ray
KW - early detection of cancer
KW - general practice
KW - lung cancer
UR - https://www.scopus.com/pages/publications/105004208337
U2 - 10.3399/BJGP.2024.0466
DO - 10.3399/BJGP.2024.0466
M3 - Article
C2 - 39740925
AN - SCOPUS:105004208337
SN - 0960-1643
VL - 75
SP - e323-e332
JO - British Journal of General Practice
JF - British Journal of General Practice
IS - 754
ER -
