Facile stoichiometric reductions in flow: An example of artemisinin

Xiaolei Fan; Victor Sans; Polina Yaseneva; Dorota D. Plaza; Jonathan Williams; Alexei Lapkin

doi:10.1021/op200373m

Facile stoichiometric reductions in flow: An example of artemisinin

Xiaolei Fan
, Victor Sans
, Polina Yaseneva
, Dorota D. Plaza
, Jonathan Williams
, Alexei Lapkin^*

^*Corresponding author for this work

Research output: Journal Publication › Article › peer-review

44 Citations (Scopus)

Abstract

Stoichiometric reduction of artemisinin to dihydroartemisinin (DHA) has been successfully transferred from batch to continuous flow conditions with a significant increase in productivity and an increase in selectivity. The DHA space-time-yield of up to 1.6 kg h ^-1 L ^-1 was attained which represents a 42 times increase in throughput compared to that of conventional batch process.

Original language	English
Pages (from-to)	1039-1042
Number of pages	4
Journal	Organic Process Research and Development
Volume	16
Issue number	5
DOIs	https://doi.org/10.1021/op200373m
Publication status	Published - 18 May 2012
Externally published	Yes

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/op200373m

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title = "Facile stoichiometric reductions in flow: An example of artemisinin",

abstract = "Stoichiometric reduction of artemisinin to dihydroartemisinin (DHA) has been successfully transferred from batch to continuous flow conditions with a significant increase in productivity and an increase in selectivity. The DHA space-time-yield of up to 1.6 kg h -1 L -1 was attained which represents a 42 times increase in throughput compared to that of conventional batch process.",

author = "Xiaolei Fan and Victor Sans and Polina Yaseneva and Plaza, \{Dorota D.\} and Jonathan Williams and Alexei Lapkin",

year = "2012",

month = may,

day = "18",

doi = "10.1021/op200373m",

language = "English",

volume = "16",

pages = "1039--1042",

journal = "Organic Process Research and Development",

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publisher = "American Chemical Society",

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T1 - Facile stoichiometric reductions in flow

T2 - An example of artemisinin

AU - Fan, Xiaolei

AU - Sans, Victor

AU - Yaseneva, Polina

AU - Plaza, Dorota D.

AU - Williams, Jonathan

AU - Lapkin, Alexei

PY - 2012/5/18

Y1 - 2012/5/18

N2 - Stoichiometric reduction of artemisinin to dihydroartemisinin (DHA) has been successfully transferred from batch to continuous flow conditions with a significant increase in productivity and an increase in selectivity. The DHA space-time-yield of up to 1.6 kg h -1 L -1 was attained which represents a 42 times increase in throughput compared to that of conventional batch process.

AB - Stoichiometric reduction of artemisinin to dihydroartemisinin (DHA) has been successfully transferred from batch to continuous flow conditions with a significant increase in productivity and an increase in selectivity. The DHA space-time-yield of up to 1.6 kg h -1 L -1 was attained which represents a 42 times increase in throughput compared to that of conventional batch process.

UR - https://www.scopus.com/pages/publications/84862101865

U2 - 10.1021/op200373m

DO - 10.1021/op200373m

M3 - Article

AN - SCOPUS:84862101865

SN - 1083-6160

VL - 16

SP - 1039

EP - 1042

JO - Organic Process Research and Development

JF - Organic Process Research and Development

IS - 5

ER -

Facile stoichiometric reductions in flow: An example of artemisinin

Abstract

ASJC Scopus subject areas

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