Excited state dependent electron transfer of a rhenium-dipyridophenazine complex intercalated between the base pairs of DNA: A time-resolved UV-visible and IR absorption investigation into the photophysics of fac-[Re(CO) 3(F2dppz)(py)]+ bound to either [poly(dA-dT)]2 or [poly(dG-dC)]2

Qian Cao; Caitriona M. Creely; E. Stephen Davies; Joanne Dyer; Timothy L. Easun; David C. Grills; David A. McGovern; Jonathan McMaster; Jonathan Pitchford; Jayden A. Smith; Xue Zhong Sun; John M. Kelly; Michael W. George

doi:10.1039/c1pp05050h

Excited state dependent electron transfer of a rhenium-dipyridophenazine complex intercalated between the base pairs of DNA: A time-resolved UV-visible and IR absorption investigation into the photophysics of fac-[Re(CO) ₃(F₂dppz)(py)]⁺ bound to either [poly(dA-dT)]₂ or [poly(dG-dC)]₂

Qian Cao
, Caitriona M. Creely
, E. Stephen Davies
, Joanne Dyer
, Timothy L. Easun
, David C. Grills
, David A. McGovern
, Jonathan McMaster
, Jonathan Pitchford
, Jayden A. Smith
, Xue Zhong Sun
, John M. Kelly
, Michael W. George

Research output: Journal Publication › Article › peer-review

32 Citations (Scopus)

Abstract

The transient species formed following excitation of fac-[Re(CO) ₃(F₂dppz)(py)]⁺ (F₂dppz = 11,12-difluorodipyrido[3,2-a:2′,3′-c]phenazine) bound to double-stranded polynucleotides [poly(dA-dT)]₂ or [poly(dG-dC)] ₂ have been studied by transient visible and infra-red spectroscopy in both the picosecond and nanosecond time domains. The latter technique has been used to monitor both the metal complex and the DNA by monitoring the regions 1900-2100 and 1500-1750 cm^-1 respectively. These data provide direct evidence for electron transfer from guanine to the excited state of the metal complex, which proceeds both on a sub-picosecond time scale and with a lifetime of 35 ps, possibly due to the involvement of two excited states. No electron transfer is found for the [poly(dA-dT)]₂ complex, although characteristic changes are seen in the DNA-region TRIR consistent with changes in the binding of the bases in the intercalation site upon excitation of the dppz-complex.

Original language	English
Pages (from-to)	1355-1364
Number of pages	10
Journal	Photochemical and Photobiological Sciences
Volume	10
Issue number	8
DOIs	https://doi.org/10.1039/c1pp05050h
Publication status	Published - Aug 2011
Externally published	Yes

ASJC Scopus subject areas

Physical and Theoretical Chemistry

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Cao, Q., Creely, C. M., Davies, E. S., Dyer, J., Easun, T. L., Grills, D. C., McGovern, D. A., McMaster, J., Pitchford, J., Smith, J. A., Sun, X. Z., Kelly, J. M., & George, M. W. (2011). Excited state dependent electron transfer of a rhenium-dipyridophenazine complex intercalated between the base pairs of DNA: A time-resolved UV-visible and IR absorption investigation into the photophysics of fac-[Re(CO) ₃(F₂dppz)(py)]⁺ bound to either [poly(dA-dT)]₂ or [poly(dG-dC)]₂. Photochemical and Photobiological Sciences, 10(8), 1355-1364. https://doi.org/10.1039/c1pp05050h

Cao, Qian ; Creely, Caitriona M. ; Davies, E. Stephen et al. / Excited state dependent electron transfer of a rhenium-dipyridophenazine complex intercalated between the base pairs of DNA : A time-resolved UV-visible and IR absorption investigation into the photophysics of fac-[Re(CO) ₃(F₂dppz)(py)]⁺ bound to either [poly(dA-dT)]₂ or [poly(dG-dC)]₂. In: Photochemical and Photobiological Sciences. 2011 ; Vol. 10, No. 8. pp. 1355-1364.

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title = "Excited state dependent electron transfer of a rhenium-dipyridophenazine complex intercalated between the base pairs of DNA: A time-resolved UV-visible and IR absorption investigation into the photophysics of fac-[Re(CO) 3(F2dppz)(py)]+ bound to either [poly(dA-dT)]2 or [poly(dG-dC)]2",

abstract = "The transient species formed following excitation of fac-[Re(CO) 3(F2dppz)(py)]+ (F2dppz = 11,12-difluorodipyrido[3,2-a:2′,3′-c]phenazine) bound to double-stranded polynucleotides [poly(dA-dT)]2 or [poly(dG-dC)] 2 have been studied by transient visible and infra-red spectroscopy in both the picosecond and nanosecond time domains. The latter technique has been used to monitor both the metal complex and the DNA by monitoring the regions 1900-2100 and 1500-1750 cm-1 respectively. These data provide direct evidence for electron transfer from guanine to the excited state of the metal complex, which proceeds both on a sub-picosecond time scale and with a lifetime of 35 ps, possibly due to the involvement of two excited states. No electron transfer is found for the [poly(dA-dT)]2 complex, although characteristic changes are seen in the DNA-region TRIR consistent with changes in the binding of the bases in the intercalation site upon excitation of the dppz-complex.",

author = "Qian Cao and Creely, \{Caitriona M.\} and Davies, \{E. Stephen\} and Joanne Dyer and Easun, \{Timothy L.\} and Grills, \{David C.\} and McGovern, \{David A.\} and Jonathan McMaster and Jonathan Pitchford and Smith, \{Jayden A.\} and Sun, \{Xue Zhong\} and Kelly, \{John M.\} and George, \{Michael W.\}",

year = "2011",

month = aug,

doi = "10.1039/c1pp05050h",

language = "English",

volume = "10",

pages = "1355--1364",

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Cao, Q, Creely, CM, Davies, ES, Dyer, J, Easun, TL, Grills, DC, McGovern, DA, McMaster, J, Pitchford, J, Smith, JA, Sun, XZ, Kelly, JM & George, MW 2011, 'Excited state dependent electron transfer of a rhenium-dipyridophenazine complex intercalated between the base pairs of DNA: A time-resolved UV-visible and IR absorption investigation into the photophysics of fac-[Re(CO) ₃(F₂dppz)(py)]⁺ bound to either [poly(dA-dT)]₂ or [poly(dG-dC)]₂', Photochemical and Photobiological Sciences, vol. 10, no. 8, pp. 1355-1364. https://doi.org/10.1039/c1pp05050h

Excited state dependent electron transfer of a rhenium-dipyridophenazine complex intercalated between the base pairs of DNA: A time-resolved UV-visible and IR absorption investigation into the photophysics of fac-[Re(CO) ₃(F₂dppz)(py)]⁺ bound to either [poly(dA-dT)]₂ or [poly(dG-dC)]₂. / Cao, Qian; Creely, Caitriona M.; Davies, E. Stephen et al.
In: Photochemical and Photobiological Sciences, Vol. 10, No. 8, 08.2011, p. 1355-1364.

Research output: Journal Publication › Article › peer-review

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AB - The transient species formed following excitation of fac-[Re(CO) 3(F2dppz)(py)]+ (F2dppz = 11,12-difluorodipyrido[3,2-a:2′,3′-c]phenazine) bound to double-stranded polynucleotides [poly(dA-dT)]2 or [poly(dG-dC)] 2 have been studied by transient visible and infra-red spectroscopy in both the picosecond and nanosecond time domains. The latter technique has been used to monitor both the metal complex and the DNA by monitoring the regions 1900-2100 and 1500-1750 cm-1 respectively. These data provide direct evidence for electron transfer from guanine to the excited state of the metal complex, which proceeds both on a sub-picosecond time scale and with a lifetime of 35 ps, possibly due to the involvement of two excited states. No electron transfer is found for the [poly(dA-dT)]2 complex, although characteristic changes are seen in the DNA-region TRIR consistent with changes in the binding of the bases in the intercalation site upon excitation of the dppz-complex.

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Cao Q, Creely CM, Davies ES, Dyer J, Easun TL, Grills DC et al. Excited state dependent electron transfer of a rhenium-dipyridophenazine complex intercalated between the base pairs of DNA: A time-resolved UV-visible and IR absorption investigation into the photophysics of fac-[Re(CO) ₃(F₂dppz)(py)]⁺ bound to either [poly(dA-dT)]₂ or [poly(dG-dC)]₂. Photochemical and Photobiological Sciences. 2011 Aug;10(8):1355-1364. doi: 10.1039/c1pp05050h