Electroacupuncture accelerated the expression of c-fos protooncogene in dopaminergic neurons in the ventral tegmental area of the rat

Qing Ping Ma; Yan Zhou; Ji Sheng Han

doi:10.3109/00207459309000577

Electroacupuncture accelerated the expression of c-fos protooncogene in dopaminergic neurons in the ventral tegmental area of the rat

Qing Ping Ma, Yan Zhou, Ji Sheng Han

Research output: Journal Publication › Article › peer-review

12 Citations (Scopus)

Abstract

The mesolimbic dopaminergic system has been implicated in mediating morphine and electroacupuncture analgesia. In the present study, Fos immunoreactivity was used as a marker of neuronal activity to investigate if electroacupuncture could activate the dopaminergic neurons in the midbrain. Electroacupuncture stimulation significantly increased the number of Fos-positive dopaminergic neurons in the ventral tegmental area (VTA), whereas no significant c-fos expression in the dopaminergic neurons was observed in the substantia nigra (SN). These results indicate that the VTA rather than the SN may play a role in mediating electroacupuncture analgesia

Original language	English
Pages (from-to)	217-222
Number of pages	6
Journal	International Journal of Neuroscience
Volume	70
Issue number	3-4
DOIs	https://doi.org/10.3109/00207459309000577
Publication status	Published - 1993
Externally published	Yes

Keywords

C-fos protooncogene
Dopamine
Electroacupuncture
Ventral tegmental area

ASJC Scopus subject areas

General Neuroscience

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10.3109/00207459309000577

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title = "Electroacupuncture accelerated the expression of c-fos protooncogene in dopaminergic neurons in the ventral tegmental area of the rat",

abstract = "The mesolimbic dopaminergic system has been implicated in mediating morphine and electroacupuncture analgesia. In the present study, Fos immunoreactivity was used as a marker of neuronal activity to investigate if electroacupuncture could activate the dopaminergic neurons in the midbrain. Electroacupuncture stimulation significantly increased the number of Fos-positive dopaminergic neurons in the ventral tegmental area (VTA), whereas no significant c-fos expression in the dopaminergic neurons was observed in the substantia nigra (SN). These results indicate that the VTA rather than the SN may play a role in mediating electroacupuncture analgesia",

keywords = "C-fos protooncogene, Dopamine, Electroacupuncture, Ventral tegmental area",

author = "Ma, \{Qing Ping\} and Yan Zhou and Han, \{Ji Sheng\}",

note = "Funding Information: All correspondences should be addressed to Dr. Qing-Ping Ma. The authors would like to thank Dr. J. S. Hong of NIEH for generously providing tyrosine hydroxylase antiserum. This work was supported by a grant from NIDA, U.S.A., DA03983, and a grant from the National Natural Science Foundation of China.",

year = "1993",

doi = "10.3109/00207459309000577",

language = "English",

volume = "70",

pages = "217--222",

journal = "International Journal of Neuroscience",

issn = "0020-7454",

publisher = "Taylor and Francis Ltd.",

number = "3-4",

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TY - JOUR

T1 - Electroacupuncture accelerated the expression of c-fos protooncogene in dopaminergic neurons in the ventral tegmental area of the rat

AU - Ma, Qing Ping

AU - Zhou, Yan

AU - Han, Ji Sheng

N1 - Funding Information: All correspondences should be addressed to Dr. Qing-Ping Ma. The authors would like to thank Dr. J. S. Hong of NIEH for generously providing tyrosine hydroxylase antiserum. This work was supported by a grant from NIDA, U.S.A., DA03983, and a grant from the National Natural Science Foundation of China.

PY - 1993

Y1 - 1993

N2 - The mesolimbic dopaminergic system has been implicated in mediating morphine and electroacupuncture analgesia. In the present study, Fos immunoreactivity was used as a marker of neuronal activity to investigate if electroacupuncture could activate the dopaminergic neurons in the midbrain. Electroacupuncture stimulation significantly increased the number of Fos-positive dopaminergic neurons in the ventral tegmental area (VTA), whereas no significant c-fos expression in the dopaminergic neurons was observed in the substantia nigra (SN). These results indicate that the VTA rather than the SN may play a role in mediating electroacupuncture analgesia

AB - The mesolimbic dopaminergic system has been implicated in mediating morphine and electroacupuncture analgesia. In the present study, Fos immunoreactivity was used as a marker of neuronal activity to investigate if electroacupuncture could activate the dopaminergic neurons in the midbrain. Electroacupuncture stimulation significantly increased the number of Fos-positive dopaminergic neurons in the ventral tegmental area (VTA), whereas no significant c-fos expression in the dopaminergic neurons was observed in the substantia nigra (SN). These results indicate that the VTA rather than the SN may play a role in mediating electroacupuncture analgesia

KW - C-fos protooncogene

KW - Dopamine

KW - Electroacupuncture

KW - Ventral tegmental area

UR - https://www.scopus.com/pages/publications/0027616583

U2 - 10.3109/00207459309000577

DO - 10.3109/00207459309000577

M3 - Article

C2 - 8063541

AN - SCOPUS:0027616583

SN - 0020-7454

VL - 70

SP - 217

EP - 222

JO - International Journal of Neuroscience

JF - International Journal of Neuroscience

IS - 3-4

ER -

Electroacupuncture accelerated the expression of c-fos protooncogene in dopaminergic neurons in the ventral tegmental area of the rat

Abstract

Keywords

ASJC Scopus subject areas

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