Co-localization of 5-HTIB/ID/IF receptors and glutamate in trigeminal ganglia in rats

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85 Citations (Scopus)


Anti-migraine triptan drugs are 5-HTIB/ID receptor agonists which are thought to block the neurotransmitter/neuropeptide release from sensory nerve terminals and directly constrict blood vessel smooth muscles. In the present study, we have investigated the anatomical basis for a possible modulation of glutamate release from trigeminal ganglion neurons by 5-HTIB/ID receptor agonists and by 5-HTIF receptor agonists, using double immunohistochemical staining technique in the rat. The majority of 5-HTIB, 5-HTID or 5-HTIF receptor positive neurons were also glutamate positive, but both 5-HTIB, 5-HTID or 5-HTIF receptor single-labeled and glutamate single-labeled neurons were observed. These results suggest that 5-HTIB/ID/IF receptor agonists may modulate glutamate release, and that one mechanism of their anti-migraine action could be the blockade of glutamate release.

Original languageEnglish
Pages (from-to)1589-1591
Number of pages3
Issue number8
Publication statusPublished - 13 Jun 2001
Externally publishedYes


  • 5-HT
  • Glutamate
  • Migraine
  • Trigeminal ganglia

ASJC Scopus subject areas

  • General Neuroscience


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