Chromosome 9p21.3 is associated with early-onset coronary heart disease in the Irish population

Weihua Meng; Anne E. Hughes; Chris C. Patterson; Christine Belton; Frank Kee; Pascal P. McKeown

doi:10.1155/2008/375617

Chromosome 9p21.3 is associated with early-onset coronary heart disease in the Irish population

Weihua Meng
, Anne E. Hughes
, Chris C. Patterson
, Christine Belton
, Frank Kee
, Pascal P. McKeown

Research output: Journal Publication › Article › peer-review

20 Citations (Scopus)

Abstract

Coronary heart disease (CHD) remains a leading cause of death across the world. A region on chromosome 9p21.3 has been recently reported to be associated with CHD. We evaluated 3 SNPs and 3 common haplotypes in the 9p21.3 region in 1494 individuals from 580 Irish families, where at least 1 member had early-onset (males ≤55yr, females ≤60yr) CHD. Genotypes were determined by multiplex SNaPshot technology. Using the combined TDT/S-TDT test, the 3 single nucleotide polymorphisms (SNP), rs10757274, rs2383206 and rs1333049, were strongly associated with early-onset CHD (p = 2.7 × 10^-6, 2.7 × 10^-6, 3.8 × 10^-7, respectively). Analysis of haplotypes by the TRANSMIT program also showed that the GGC haplotype was associated with early-onset CHD (p = 7.9 × 10^-7). In conclusion, using a family-based approach in the Irish population, we have confirmed previous reports of association between a region on chromosome 9p21.3 and early-onset CHD.

Original language	English
Pages (from-to)	81-85
Number of pages	5
Journal	Disease Markers
Volume	25
Issue number	2
DOIs	https://doi.org/10.1155/2008/375617
Publication status	Published - 2008
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Free Keywords

Chromosome 9p21.3
Coronary heart disease
Genetics

ASJC Scopus subject areas

Molecular Biology
Genetics
Clinical Biochemistry
Biochemistry, medical

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10.1155/2008/375617

Cite this

@article{1a8159a6e1374b68a274daa34dd0c1aa,

title = "Chromosome 9p21.3 is associated with early-onset coronary heart disease in the Irish population",

abstract = "Coronary heart disease (CHD) remains a leading cause of death across the world. A region on chromosome 9p21.3 has been recently reported to be associated with CHD. We evaluated 3 SNPs and 3 common haplotypes in the 9p21.3 region in 1494 individuals from 580 Irish families, where at least 1 member had early-onset (males ≤55yr, females ≤60yr) CHD. Genotypes were determined by multiplex SNaPshot technology. Using the combined TDT/S-TDT test, the 3 single nucleotide polymorphisms (SNP), rs10757274, rs2383206 and rs1333049, were strongly associated with early-onset CHD (p = 2.7 × 10-6, 2.7 × 10-6, 3.8 × 10-7, respectively). Analysis of haplotypes by the TRANSMIT program also showed that the GGC haplotype was associated with early-onset CHD (p = 7.9 × 10-7). In conclusion, using a family-based approach in the Irish population, we have confirmed previous reports of association between a region on chromosome 9p21.3 and early-onset CHD.",

keywords = "Chromosome 9p21.3, Coronary heart disease, Genetics",

author = "Weihua Meng and Hughes, \{Anne E.\} and Patterson, \{Chris C.\} and Christine Belton and Frank Kee and McKeown, \{Pascal P.\}",

note = "Funding Information: Coronary heart disease (CHD) remains a leading cause of death across the world. A region on chromosome 9p21.3 has been recently reported to be associated with CHD. We evaluated 3 SNPs and 3 common haplotypes in the 9p21.3 region in 1494 individuals from 580 Irish families, where at least 1 member had early-onset (males ≤55yr, females ≤60yr) CHD. Genotypes were determined by multiplex SNaPshot technology. Using the combined TDT/S-TDT test, the 3 single nucleotide polymorphisms (SNP), rs10757274, rs2383206 and rs1333049, were strongly associated with early-onset CHD ( p = 2.7 × 10 -6 , 2.7 × 10 -6 , 3.8 × 10 -7 , respectively). Analysis of haplotypes by the TRANSMIT program also showed that the GGC haplotype was associated with early-onset CHD ( p = 7.9 × 10 -7 ). In conclusion, using a family-based approach in the Irish population, we have confirmed previous reports of association between a region on chromosome 9p21.3 and early-onset CHD. Coronary heart disease chromosome 9p21.3 genetics Northern Ireland Research and Development Office Royal Victoria Hospital Research Fellowship http://dx.doi.org/10.13039/501100000415 Northern Ireland Chest, Heart and Stroke Association Heart Trust Fund",

year = "2008",

doi = "10.1155/2008/375617",

language = "English",

volume = "25",

pages = "81--85",

journal = "Disease Markers",

issn = "0278-0240",

publisher = "Hindawi Limited",

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TY - JOUR

T1 - Chromosome 9p21.3 is associated with early-onset coronary heart disease in the Irish population

AU - Meng, Weihua

AU - Hughes, Anne E.

AU - Patterson, Chris C.

AU - Belton, Christine

AU - Kee, Frank

AU - McKeown, Pascal P.

N1 - Funding Information: Coronary heart disease (CHD) remains a leading cause of death across the world. A region on chromosome 9p21.3 has been recently reported to be associated with CHD. We evaluated 3 SNPs and 3 common haplotypes in the 9p21.3 region in 1494 individuals from 580 Irish families, where at least 1 member had early-onset (males ≤55yr, females ≤60yr) CHD. Genotypes were determined by multiplex SNaPshot technology. Using the combined TDT/S-TDT test, the 3 single nucleotide polymorphisms (SNP), rs10757274, rs2383206 and rs1333049, were strongly associated with early-onset CHD ( p = 2.7 × 10 -6 , 2.7 × 10 -6 , 3.8 × 10 -7 , respectively). Analysis of haplotypes by the TRANSMIT program also showed that the GGC haplotype was associated with early-onset CHD ( p = 7.9 × 10 -7 ). In conclusion, using a family-based approach in the Irish population, we have confirmed previous reports of association between a region on chromosome 9p21.3 and early-onset CHD. Coronary heart disease chromosome 9p21.3 genetics Northern Ireland Research and Development Office Royal Victoria Hospital Research Fellowship http://dx.doi.org/10.13039/501100000415 Northern Ireland Chest, Heart and Stroke Association Heart Trust Fund

PY - 2008

Y1 - 2008

N2 - Coronary heart disease (CHD) remains a leading cause of death across the world. A region on chromosome 9p21.3 has been recently reported to be associated with CHD. We evaluated 3 SNPs and 3 common haplotypes in the 9p21.3 region in 1494 individuals from 580 Irish families, where at least 1 member had early-onset (males ≤55yr, females ≤60yr) CHD. Genotypes were determined by multiplex SNaPshot technology. Using the combined TDT/S-TDT test, the 3 single nucleotide polymorphisms (SNP), rs10757274, rs2383206 and rs1333049, were strongly associated with early-onset CHD (p = 2.7 × 10-6, 2.7 × 10-6, 3.8 × 10-7, respectively). Analysis of haplotypes by the TRANSMIT program also showed that the GGC haplotype was associated with early-onset CHD (p = 7.9 × 10-7). In conclusion, using a family-based approach in the Irish population, we have confirmed previous reports of association between a region on chromosome 9p21.3 and early-onset CHD.

AB - Coronary heart disease (CHD) remains a leading cause of death across the world. A region on chromosome 9p21.3 has been recently reported to be associated with CHD. We evaluated 3 SNPs and 3 common haplotypes in the 9p21.3 region in 1494 individuals from 580 Irish families, where at least 1 member had early-onset (males ≤55yr, females ≤60yr) CHD. Genotypes were determined by multiplex SNaPshot technology. Using the combined TDT/S-TDT test, the 3 single nucleotide polymorphisms (SNP), rs10757274, rs2383206 and rs1333049, were strongly associated with early-onset CHD (p = 2.7 × 10-6, 2.7 × 10-6, 3.8 × 10-7, respectively). Analysis of haplotypes by the TRANSMIT program also showed that the GGC haplotype was associated with early-onset CHD (p = 7.9 × 10-7). In conclusion, using a family-based approach in the Irish population, we have confirmed previous reports of association between a region on chromosome 9p21.3 and early-onset CHD.

KW - Chromosome 9p21.3

KW - Coronary heart disease

KW - Genetics

UR - https://www.scopus.com/pages/publications/55449093561

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DO - 10.1155/2008/375617

M3 - Article

C2 - 18957718

AN - SCOPUS:55449093561

SN - 0278-0240

VL - 25

SP - 81

EP - 85

JO - Disease Markers

JF - Disease Markers

IS - 2

ER -

Chromosome 9p21.3 is associated with early-onset coronary heart disease in the Irish population

Abstract

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