Chromosome 9p21.3 is associated with early-onset coronary heart disease in the Irish population

Weihua Meng, Anne E. Hughes, Chris C. Patterson, Christine Belton, Frank Kee, Pascal P. McKeown

Research output: Journal PublicationArticlepeer-review

20 Citations (Scopus)


Coronary heart disease (CHD) remains a leading cause of death across the world. A region on chromosome 9p21.3 has been recently reported to be associated with CHD. We evaluated 3 SNPs and 3 common haplotypes in the 9p21.3 region in 1494 individuals from 580 Irish families, where at least 1 member had early-onset (males ≤55yr, females ≤60yr) CHD. Genotypes were determined by multiplex SNaPshot technology. Using the combined TDT/S-TDT test, the 3 single nucleotide polymorphisms (SNP), rs10757274, rs2383206 and rs1333049, were strongly associated with early-onset CHD (p = 2.7 × 10-6, 2.7 × 10-6, 3.8 × 10-7, respectively). Analysis of haplotypes by the TRANSMIT program also showed that the GGC haplotype was associated with early-onset CHD (p = 7.9 × 10-7). In conclusion, using a family-based approach in the Irish population, we have confirmed previous reports of association between a region on chromosome 9p21.3 and early-onset CHD.

Original languageEnglish
Pages (from-to)81-85
Number of pages5
JournalDisease Markers
Issue number2
Publication statusPublished - 2008
Externally publishedYes


  • Chromosome 9p21.3
  • Coronary heart disease
  • Genetics

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Clinical Biochemistry
  • Biochemistry, medical


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