An Overview of the Bioactivities of Gedunin

Yong Sze Ong; Kooi Yeong Khaw; Loh Teng Hern Tan; Peng Nian Yew; Kai Boon Tan; Wei Hsum Yap; Siah Ying Tang; Liang Ee Low; Learn Han Lee; Bey Hing Goh

doi:10.1007/978-3-030-54027-2_16

An Overview of the Bioactivities of Gedunin

Yong Sze Ong
, Kooi Yeong Khaw
, Loh Teng Hern Tan
, Peng Nian Yew
, Kai Boon Tan
, Wei Hsum Yap
, Siah Ying Tang
, Liang Ee Low
, Learn Han Lee
, Bey Hing Goh^*

^*Corresponding author for this work

Research output: Chapter in Book/Conference proceeding › Book Chapter › peer-review

1 Citation (Scopus)

Abstract

Gedunin is a naturally occurring pentacyclic triterpenoid secondary metabolite presents in Meliaceae family. Since the first isolation and characterization of this compound at 1960s, the chemical synthesis and bioactive properties of this compound have been continuing researched. The plant has been historically used as the folk medicine to treat malaria and infectious diseases. Evidence-based pharmacology study showed that gedunin and its derivatives exerted enormous potential in the treatment of cancer, neurodegenerative and infectious diseases. Considering this year marks 60 years since the isolation of gedunin, this review presents an update of the bioactivity of gedunin and its derivatives with future prospect of this bioactive compound.

Original language	English
Title of host publication	Advanced Structured Materials
Publisher	Springer Science and Business Media Deutschland GmbH
Pages	563-586
Number of pages	24
DOIs	https://doi.org/10.1007/978-3-030-54027-2_16
Publication status	Published - 2021
Externally published	Yes

Publication series

Name	Advanced Structured Materials
Volume	140
ISSN (Print)	1869-8433
ISSN (Electronic)	1869-8441

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Free Keywords

Anti-cancer
Bioactivities
Gedunin
Pharmacology
Triterpenoid

ASJC Scopus subject areas

General Materials Science

Access to Document

10.1007/978-3-030-54027-2_16

Cite this

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title = "An Overview of the Bioactivities of Gedunin",

abstract = "Gedunin is a naturally occurring pentacyclic triterpenoid secondary metabolite presents in Meliaceae family. Since the first isolation and characterization of this compound at 1960s, the chemical synthesis and bioactive properties of this compound have been continuing researched. The plant has been historically used as the folk medicine to treat malaria and infectious diseases. Evidence-based pharmacology study showed that gedunin and its derivatives exerted enormous potential in the treatment of cancer, neurodegenerative and infectious diseases. Considering this year marks 60 years since the isolation of gedunin, this review presents an update of the bioactivity of gedunin and its derivatives with future prospect of this bioactive compound.",

keywords = "Anti-cancer, Bioactivities, Gedunin, Pharmacology, Triterpenoid",

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year = "2021",

doi = "10.1007/978-3-030-54027-2\_16",

language = "English",

series = "Advanced Structured Materials",

publisher = "Springer Science and Business Media Deutschland GmbH",

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T1 - An Overview of the Bioactivities of Gedunin

AU - Ong, Yong Sze

AU - Khaw, Kooi Yeong

AU - Tan, Loh Teng Hern

AU - Yew, Peng Nian

AU - Tan, Kai Boon

AU - Yap, Wei Hsum

AU - Tang, Siah Ying

AU - Low, Liang Ee

AU - Lee, Learn Han

AU - Goh, Bey Hing

PY - 2021

Y1 - 2021

N2 - Gedunin is a naturally occurring pentacyclic triterpenoid secondary metabolite presents in Meliaceae family. Since the first isolation and characterization of this compound at 1960s, the chemical synthesis and bioactive properties of this compound have been continuing researched. The plant has been historically used as the folk medicine to treat malaria and infectious diseases. Evidence-based pharmacology study showed that gedunin and its derivatives exerted enormous potential in the treatment of cancer, neurodegenerative and infectious diseases. Considering this year marks 60 years since the isolation of gedunin, this review presents an update of the bioactivity of gedunin and its derivatives with future prospect of this bioactive compound.

AB - Gedunin is a naturally occurring pentacyclic triterpenoid secondary metabolite presents in Meliaceae family. Since the first isolation and characterization of this compound at 1960s, the chemical synthesis and bioactive properties of this compound have been continuing researched. The plant has been historically used as the folk medicine to treat malaria and infectious diseases. Evidence-based pharmacology study showed that gedunin and its derivatives exerted enormous potential in the treatment of cancer, neurodegenerative and infectious diseases. Considering this year marks 60 years since the isolation of gedunin, this review presents an update of the bioactivity of gedunin and its derivatives with future prospect of this bioactive compound.

KW - Anti-cancer

KW - Bioactivities

KW - Gedunin

KW - Pharmacology

KW - Triterpenoid

UR - https://www.scopus.com/pages/publications/85097900891

U2 - 10.1007/978-3-030-54027-2_16

DO - 10.1007/978-3-030-54027-2_16

M3 - Book Chapter

AN - SCOPUS:85097900891

T3 - Advanced Structured Materials

SP - 563

EP - 586

BT - Advanced Structured Materials

PB - Springer Science and Business Media Deutschland GmbH

ER -

An Overview of the Bioactivities of Gedunin

Abstract

Publication series

UN SDGs

Free Keywords

ASJC Scopus subject areas

Access to Document

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