A-fibres sprouting from lamina I into lamina II of spinal dorsal horn after peripheral nerve injury in rats

Qing Ping Ma; Li Tian

doi:10.1016/S0006-8993(01)02420-9

A-fibres sprouting from lamina I into lamina II of spinal dorsal horn after peripheral nerve injury in rats

Qing Ping Ma
, Li Tian

Research output: Journal Publication › Article › peer-review

11 Citations (Scopus)

Abstract

We have examined the labeling pattern in the spinal dorsal horn by an intra-sciatic nerve injection of cholera toxin B subunit conjugated horseradish peroxidase (HRP) after transection of the posterior cutaneous nerve and inferior gluteal nerve, and found that the cholera toxin B subunit conjugated HRP labeling in lamina I was expanding into lamina II and there was a shrinking gap between lamina I and lamina III. This result suggests that A-fibre sprouting arise after peripheral nerve injury, but mainly from small calibre Aδ-fibres which terminate in lamina I.

Original language	English
Pages (from-to)	137-140
Number of pages	4
Journal	Brain Research
Volume	904
Issue number	1
DOIs	https://doi.org/10.1016/S0006-8993(01)02420-9
Publication status	Published - 15 Jun 2001
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Free Keywords

Bandeiraea simplicifolia isolectin B4 (IB4)
Cholera toxin B subunit (CTB)
Dorsal root ganglia (DRG)
Primary afferent

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

Access to Document

10.1016/S0006-8993(01)02420-9

Cite this

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title = "A-fibres sprouting from lamina I into lamina II of spinal dorsal horn after peripheral nerve injury in rats",

abstract = "We have examined the labeling pattern in the spinal dorsal horn by an intra-sciatic nerve injection of cholera toxin B subunit conjugated horseradish peroxidase (HRP) after transection of the posterior cutaneous nerve and inferior gluteal nerve, and found that the cholera toxin B subunit conjugated HRP labeling in lamina I was expanding into lamina II and there was a shrinking gap between lamina I and lamina III. This result suggests that A-fibre sprouting arise after peripheral nerve injury, but mainly from small calibre Aδ-fibres which terminate in lamina I.",

keywords = "Bandeiraea simplicifolia isolectin B4 (IB4), Cholera toxin B subunit (CTB), Dorsal root ganglia (DRG), Primary afferent",

author = "Ma, \{Qing Ping\} and Li Tian",

note = "Funding Information: This study was supported by Medical Research Council of UK. We thank Professor C.J. Woolf for his support and valuable comments, Mrs P. Ainsworth, Mr A. Allchorne and Ms J.M. Middleton for technical help.",

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doi = "10.1016/S0006-8993(01)02420-9",

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TY - JOUR

T1 - A-fibres sprouting from lamina I into lamina II of spinal dorsal horn after peripheral nerve injury in rats

AU - Ma, Qing Ping

AU - Tian, Li

N1 - Funding Information: This study was supported by Medical Research Council of UK. We thank Professor C.J. Woolf for his support and valuable comments, Mrs P. Ainsworth, Mr A. Allchorne and Ms J.M. Middleton for technical help.

PY - 2001/6/15

Y1 - 2001/6/15

N2 - We have examined the labeling pattern in the spinal dorsal horn by an intra-sciatic nerve injection of cholera toxin B subunit conjugated horseradish peroxidase (HRP) after transection of the posterior cutaneous nerve and inferior gluteal nerve, and found that the cholera toxin B subunit conjugated HRP labeling in lamina I was expanding into lamina II and there was a shrinking gap between lamina I and lamina III. This result suggests that A-fibre sprouting arise after peripheral nerve injury, but mainly from small calibre Aδ-fibres which terminate in lamina I.

AB - We have examined the labeling pattern in the spinal dorsal horn by an intra-sciatic nerve injection of cholera toxin B subunit conjugated horseradish peroxidase (HRP) after transection of the posterior cutaneous nerve and inferior gluteal nerve, and found that the cholera toxin B subunit conjugated HRP labeling in lamina I was expanding into lamina II and there was a shrinking gap between lamina I and lamina III. This result suggests that A-fibre sprouting arise after peripheral nerve injury, but mainly from small calibre Aδ-fibres which terminate in lamina I.

KW - Bandeiraea simplicifolia isolectin B4 (IB4)

KW - Cholera toxin B subunit (CTB)

KW - Dorsal root ganglia (DRG)

KW - Primary afferent

UR - https://www.scopus.com/pages/publications/0035876028

U2 - 10.1016/S0006-8993(01)02420-9

DO - 10.1016/S0006-8993(01)02420-9

M3 - Article

C2 - 11516419

AN - SCOPUS:0035876028

SN - 0006-8993

VL - 904

SP - 137

EP - 140

JO - Brain Research

JF - Brain Research

IS - 1

ER -

A-fibres sprouting from lamina I into lamina II of spinal dorsal horn after peripheral nerve injury in rats

Abstract

UN SDGs

Free Keywords

ASJC Scopus subject areas

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