基于OCT对帕金森病患者视网膜外丛状层影像特征的初步研究

Objective: To quantity analyze the image features including the thickness and texture in the retinal outer plexiform layer (OPL) of Parkinson's disease (PD) patients by optical coherence tomography (OCT). Methods: A cross-sectional study was conducted in the Eye Hospital of Wenzhou Medical University from November 2022 to March 2023. A total of 59 consecutive eyes of 59 patients with PD were enrolled as PD group and 35 eyes of 35 age-and gender-matched healthy subjects were enrolled in the healthy control group. OCT was used to obtain the image features within 3 mm diameter area around the macula through circular scanning at the macula of all subjects. The differences in OPL image features between PD and healthy control groups were compared by t-test, and the correlation of mean values from selected features with the clinical measures were evaluated by Pearson and Spearman correlation analysis. Results: The OPL thickness of PD patients was 11.22±3.95 μm at 3 mm area around the macula, which was evidently higher than 9.37±1.07 μm in the healthy control group (t=-3.36, P=0.001). Multiple texture features between the two groups were significantly differed between the PD group and healthy control group, the inverse difference normalized (IDN) feature value increased, while values of the run length non-uniformity normalized (RLNN) and run percentage (RP) features decreased (all P<0.001). OPL thickness and IDN was positively correlated with Unified Parkinson's Disease Rating (UPDRS) score (r=0.24, P=0.019; r=0.61, P<0.001), UPDRS III score (r=0.27, P=0.010; r=0.62, P<0.001), disease duration (r=0.26, P=0.013; r=0.66, P<0.001) and Hoehn-Yahr score (r=0.28, P=0.006; r=0.70, P<0.001). RLNN and RP were negatively correlated with UPDRS score (r=-0.62, -0.61, both P<0.001), UPDRS III score (r=-0.62, -0.61, both P<0.001), disease duration (r=-0.68, -0.67, both P<0.001) and Hoehn-Yahr score (r=-0.69, -0.69, both P<0.001). Conclusions: The macular OPL thickness of PD patients increased, and the IDN feature value increased, while values of the RLNN and RP features decreased, which were correlated with Hoehn-Yahr score, disease duration, UPDRS and part III score.